Abstract

DEVELOPMENTAL AND PILOT RESEARCH COMPONENT: As TCORS research progresses and a new base of knowledge develops, further research opportunities will arise. Such opportunities will include new research ideas, validation studies, and interventional projects. To foster a continuation of scientific inquiry related to both TCORS goals and FDA needs, A-TRAC proposes to develop a Developmental and Pilot Research Component to promote the exploration of new ideas by developing and implementing pilot research projects. Similar to the Center's overall structure, these pilot projects will operate across major research proposals and will be supported by A-TRAC at different academic institutions, both within and external to the TCORS network. In collaboration with the Administrative Core, the Developmental and Pilot Research Component will utilize the already existing AHA plan of solicitation and peer-review to select individual projects for funding. These projects will be expected to be both scientifically sound and rigorous, and must also address the research priorities of the FDA. The AHA has strong competencies in research review and administration that will allow for an effective partnership with the FDA .

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
4P50HL120163-04
Application #
9133452
Study Section
Special Emphasis Panel (ZRG1-BDCN-A)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
4
Fiscal Year
2016
Total Cost
$406,277
Indirect Cost
$5,231

  Institution

Name
American Heart Association
Department
Type
DUNS #
073284507
City
Dallas
State
TX
Country
United States
Zip Code
75231

  Publications

Riggs, Daniel W; Yeager, Ray A; Bhatnagar, Aruni (2018) Defining the Human Envirome: An Omics Approach for Assessing the Environmental Risk of Cardiovascular Disease. Circ Res 122:1259-1275
Fetterman, Jessica L; Weisbrod, Robert M; Feng, Bihua et al. (2018) Flavorings in Tobacco Products Induce Endothelial Cell Dysfunction. Arterioscler Thromb Vasc Biol 38:1607-1615
Ma, Jennie Z; Hart, Joy L; Walker, Kandi L et al. (2018) Perceived health risks of electronic nicotine delivery systems (ENDS) users: The role of cigarette smoking status. Addict Behav :
Wan, Ma; Bennett, Brian D; Pittman, Gary S et al. (2018) Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type-Specific Enhancer Activation and Gene Expression. Environ Health Perspect 126:047015
Ko, Darae; Preis, Sarah R; Lubitz, Steven A et al. (2018) Relation of Orthostatic Hypotension With New-Onset Atrial Fibrillation (From the Framingham Heart Study). Am J Cardiol 121:596-601
Mead, Erin L; Cruz-Cano, Raul; Groom, Allison et al. (2018) Responses to cigarette health warning labels, harm perceptions and knowledge in a national sample of pregnant and non-pregnant women of reproductive age. Addict Behav 90:10-13
Kamimura, Daisuke; Cain, Loretta R; Mentz, Robert J et al. (2018) Cigarette Smoking and Incident Heart Failure: Insights From the Jackson Heart Study. Circulation 137:2572-2582
Nayor, Matthew; Enserro, Danielle M; Xanthakis, Vanessa et al. (2018) Comorbidities and Cardiometabolic Disease: Relationship With Longitudinal Changes in Diastolic Function. JACC Heart Fail 6:317-325
Hart, Joy L; Walker, Kandi L; Sears, Clara G et al. (2018) The 'state' of tobacco: Perceptions of tobacco among Appalachian youth in Kentucky. Tob Prev Cessat 4:
Olmedo, Pablo; Goessler, Walter; Tanda, Stefan et al. (2018) Metal Concentrations in e-Cigarette Liquid and Aerosol Samples: The Contribution of Metallic Coils. Environ Health Perspect 126:027010

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