The goals of the Statistics and Data Management Core are: 1) to provide for all investigators doing CCNMD studies access to statistical support for the design, analysis and interpretation of their studies; 2) to facilitate interactions, as needed, between CCNMD investigators and statistical collaborators in various departments at the University of Pittsburgh and other Pittsburgh area institutions; 3) to develop innovative methodological research in statistics to advance CCNMD research; and 4) to manage the databases maintained for the Brain Bank Core-B and the Clinical Services Core-C. The personnel in the Statistics and Data Management Core include: a) senior faculty from the Department of Statistics at the University of Pittsburgh having extensive research expertise in statistics and its applications in neuroscience and psychiatry; b) Statistics faculty with computational statistics expertise; and c) senior database administrators with extensive experience in managing multi-project center databases. Proposed aims for the methodological projects in statistics that the Statistics and Data Management Core will examine include: 1) improved designs and estimators for stereological studies; 2) development of new adaptive designs, with an emphasis on fostering their use in tissue and animal studies; and 3) exploration of the possible applications of integrative and data mining techniques for evaluating combined data sets from a number of postmortem studies facilitated by the Brain Bank Core-B, and from the clinical and research data maintained by the Clinical Services Core-C.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH045156-15
Application #
7553424
Study Section
Project Start
Project End
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
15
Fiscal Year
2004
Total Cost
$164,294
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Cai, HuaLin; Zhou, Xiang; Dougherty, George G et al. (2018) Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia. Psychoneuroendocrinology 90:43-51
Stevenson, J M; Reilly, J L; Harris, M S H et al. (2016) Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes. Transl Psychiatry 6:e739
Lizano, Paulo L; Keshavan, Matcheri S; Tandon, Neeraj et al. (2016) Angiogenic and immune signatures in plasma of young relatives at familial high-risk for psychosis and first-episode patients: A preliminary study. Schizophr Res 170:115-22
Bishop, Jeffrey R; Reilly, James L; Harris, Margret S H et al. (2015) Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia. Psychopharmacology (Berl) 232:145-54
Horton, Leslie E; Tarbox, Sarah I; Olino, Thomas M et al. (2015) Trajectories of premorbid childhood and adolescent functioning in schizophrenia-spectrum psychoses: A first-episode study. Psychiatry Res 227:339-46
Hall, Nathan; Colby, Carol (2014) S-cone visual stimuli activate superior colliculus neurons in old world monkeys: implications for understanding blindsight. J Cogn Neurosci 26:1234-56
Subramanian, Janani; Colby, Carol L (2014) Shape selectivity and remapping in dorsal stream visual area LIP. J Neurophysiol 111:613-27
Berdyyeva, Tamara K; Olson, Carl R (2014) Intracortical microstimulation of supplementary eye field impairs ability of monkeys to make serially ordered saccades. J Neurophysiol 111:1529-40
Lencer, Rebekka; Bishop, Jeffrey R; Harris, Margret S H et al. (2014) Association of variants in DRD2 and GRM3 with motor and cognitive function in first-episode psychosis. Eur Arch Psychiatry Clin Neurosci 264:345-55
Richard, Annette E; Carter, Cameron S; Cohen, Jonathan D et al. (2013) Persistence, diagnostic specificity and genetic liability for context-processing deficits in schizophrenia. Schizophr Res 147:75-80

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