We propose the creation of an HIV neurobehavioral Research Center (HNRC under the aegis of the School of Medicine of the University of California At San Diego, (UCSD). Collaborating with UCSD will be investigators from the Naval Hospital, San Diego, the San Diego VA Medical Center, Scripps Clinic and Research Foundation, The Salk Institute, San Diego State University, and the University of Southern California. The broad goals of the HNRC are to examine the etiology, pathogenesis, natural history, and features of neurobehavioral disturbance associated with HIV infection. We define neurobehavioral broadly as embracing phenomena which can be appreciated by neurologic examination, neuropsychometry, brain imaging, electrophysiology, psychiatric assessment, and neuropathology. These general objectives will be addressed through a set of core assessments of 500 HIV antibody positive (HIV+) and negative (HIV-) men, to be conducted semi-annually for a period of five years. Subjects will include Navy members who have undergone routine HIV screening, among whom will be a unique group of 200 dated seroconverters. To these 200 will be added 90 undated Navy HIV carriers and 50 HIV- controls from the Navy. A sample of at risk civilians will also be examined, of whom 120 will be HIV+ and 40 HIV-. Added to the core assessments will be more detailed studies of selected subjects by a set of projects which will probe more deeply into neurological, psychiatric, risk factors, and predictive mathematical models. The significance of the HNRC derives from the importance of understanding the neurobehavioral correlates of HIV both for clinical and public policy determination; from the comprehensive scope of the multidisciplinary approach to neurobehavioral issues; from the collection of an unusually strong group of biobehavioral scientists from many disciplines, and from the availability of a unique sample of unselected, dated seroconverters from the U.S. Navy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH045294-04
Application #
3107326
Study Section
Special Emphasis Panel (SRCM (03))
Project Start
1989-06-01
Project End
1994-05-31
Budget Start
1992-08-01
Budget End
1993-05-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Joseph, Jeymohan; Cinque, Paola; Colosi, Deborah et al. (2016) Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA. J Virus Erad 2:243-250
Bharti, Ajay R; Woods, Steven Paul; Ellis, Ronald J et al. (2016) Fibroblast growth factors 1 and 2 in cerebrospinal fluid are associated with HIV disease, methamphetamine use, and neurocognitive functioning. HIV AIDS (Auckl) 8:93-9
Weinrich, James D; Klein, Fritz; McCutchan, J Allen et al. (2014) Cluster Analysis of the Klein Sexual Orientation Grid in Clinical and Nonclinical Samples: When Bisexuality Is Not Bisexuality. J Bisex 14:349-372
Wrasidlo, Wolf; Crews, Leslie A; Tsigelny, Igor F et al. (2014) Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol 171:5757-73
Klein, Fritz; Weinrich, James D (2014) Homogeneous Gynephiles and Heterogeneous Androphiles: A Factor Analysis of Differences and Similarities in Attractions to the Sexes as a Function of Sexual Orientation. J Bisex 14:468-501
Fields, Jerel; Dumaop, Wilmar; Rockenstein, Edward et al. (2013) Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. J Neurovirol 19:89-101
Desplats, Paula; Dumaop, Wilmar; Smith, David et al. (2013) Molecular and pathologic insights from latent HIV-1 infection in the human brain. Neurology 80:1415-23
Gelman, Benjamin B; Lisinicchia, Joshua G; Morgello, Susan et al. (2013) Neurovirological correlation with HIV-associated neurocognitive disorders and encephalitis in a HAART-era cohort. J Acquir Immune Defic Syndr 62:487-95
Soontornniyomkij, Virawudh; Everall, Ian P; Moore, David J et al. (2012) Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders. J Neurovirol 18:313-22
Soontornniyomkij, Virawudh; Moore, David J; Gouaux, Ben et al. (2012) Cerebral ?-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ?4 carriers. AIDS 26:2327-35

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