Abstract

The main goal of this proposal is to bring a variety of approaches based on genetically modified mice to bear on the study of how genes control synapse formation, synaptic fine tuning, learning, memory, emotional state, and long-term synaptic plasticity. In so doing, we will be testing, in a number of different and synergistic ways, one central idea; that several, seemingly distinct and apparently unrelated biological processes - development, the fine tuning of a sensory representation in the brain, memory storage and stress related depressive states - reflect, to a large extent, a common set of molecular, genetic, and cellular mechanisms that are expressed in different contexts and in distinct neural circuits. Underlying and unifying these diverse processes is the central importance of long-term synaptic plasticity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH050733-09
Application #
6528789
Study Section
Special Emphasis Panel (ZMH1-BRB-I (03))
Program Officer
Nadler, Laurie S
Project Start
1994-09-20
Project End
2004-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
9
Fiscal Year
2002
Total Cost
$2,222,846
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Neurosciences
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Caron, Sophie J C; Ruta, Vanessa; Abbott, L F et al. (2013) Random convergence of olfactory inputs in the Drosophila mushroom body. Nature 497:113-7
Chi, Xuan; Hadjantonakis, Anna-Katerina; Wu, Zaiqi et al. (2009) A transgenic mouse that reveals cell shape and arrangement during ureteric bud branching. Genesis 47:61-6
Huang, Yan-You; Kandel, Eric R (2007) Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis. Learn Mem 14:497-503
Huang, Yan-You; Kandel, Eric R (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. J Neurosci 27:3111-9
Yoshida, Yutaka; Han, Barbara; Mendelsohn, Monica et al. (2006) PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron 52:775-88
Lu, Fang-Min; Hawkins, Robert D (2006) Presynaptic and postsynaptic Ca(2+) and CamKII contribute to long-term potentiation at synapses between individual CA3 neurons. Proc Natl Acad Sci U S A 103:4264-9
Shumyatsky, Gleb P; Malleret, Gael; Shin, Ryong-Moon et al. (2005) stathmin, a gene enriched in the amygdala, controls both learned and innate fear. Cell 123:697-709
Huang, Yan-You; Kandel, Eric R (2005) Theta frequency stimulation induces a local form of late phase LTP in the CA1 region of the hippocampus. Learn Mem 12:587-93
Wang, Hong-Gang; Lu, Fang-Min; Jin, Iksung et al. (2005) Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins. Neuron 45:389-403
Huang, Yan-You; Kandel, Eric R (2005) Theta frequency stimulation up-regulates the synaptic strength of the pathway from CA1 to subiculum region of hippocampus. Proc Natl Acad Sci U S A 102:232-7

Showing the most recent 10 out of 50 publications