Abstract

The aim of the Biosocial Development Unit is to conduct studies on the development and microevolution of aggressive behavior in mice that have been selectively bred for the expression or inhibition of aggressive behavior.
The specific aims i n this Unit are: 1. To examine how genetic background, neonatal stimulation, and postnatal environments interact to produce stable inter-individual differences in adult social and maternal behaviors. 2. To examine how these same factors affect physiological systems using advanced techniques of neurobiological analysis and non-invasive optical brain imaging, and to relate these effects to bi-directional changes in behavioral systems. 3. To identify biological and environmental conditions under which the transfer of stable patterns of adaptation from parents to offspring is either favored or attenuated; To clarify possible windows of change in development and across generations which are related to comparable studies of human ontogeny and intergenerational development; and 4. To identify candidate genes, using biological, biochemical, and molecular techniques, that may modulate experiential influences in the development of high and low-aggressive mouse lines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH052429-08
Application #
6358514
Study Section
Project Start
2000-09-25
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
8
Fiscal Year
2000
Total Cost
$81,325
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Copping, Kristine E; Kurtz-Costes, Beth; Rowley, Stephanie J et al. (2013) Age and Race Differences in Racial Stereotype Awareness and Endorsement. J Appl Soc Psychol 43:971-980
Xie, Hongling; Drabick, Deborah A G; Chen, Diane (2011) Developmental trajectories of aggression from late childhood through adolescence: similarities and differences across gender. Aggress Behav 37:387-404
Nehrenberg, Derrick L; Rodriguiz, Ramona M; Cyr, Michel et al. (2009) An anxiety-like phenotype in mice selectively bred for aggression. Behav Brain Res 201:179-91
Estell, David B; Farmer, Thomas W; Cairns, Beverley D (2007) Bullies and victims in rural African American youth: behavioral characteristics and social network placement. Aggress Behav 33:145-59
Xie, Hongling; Li, Yan; Boucher, Signe M et al. (2006) What makes a girl (or a boy) popular (or unpopular)? African American children's perceptions and developmental differences. Dev Psychol 42:599-612
Farmer, Thomas W; Price, LeShawndra N; O'Neal, Keri K et al. (2004) Exploring risk in early adolescent African American youth. Am J Community Psychol 33:51-9
Gottlieb, Gilbert; Blair, Clancy (2004) How early experience matters in intellectual development in the case of poverty. Prev Sci 5:245-52
Cadwallader, Tom W; Farmer, Thomas W; Cairns, Beverley D (2003) The transition to high school: a prodigal analysis of developmental pathways. New Dir Child Adolesc Dev :63-74
Farmer, Thomas W; Estell, David B; Bishop, Jennifer L et al. (2003) Rejected bullies or popular leaders? The social relations of aggressive subtypes of rural african american early adolescents. Dev Psychol 39:992-1004
Gottlieb, Gilbert; Halpern, Carolyn Tucker (2002) A relational view of causality in normal and abnormal development. Dev Psychopathol 14:421-35

Showing the most recent 10 out of 22 publications