Abstract

This proposal seeks to examine the interrelations of biological, psychological, and social functioning in a cohort of 100 infants from 6 months to 2 years, and a second cross-sectional cohort of 150 subjects at 6, 15, and 24 months of age. The purpose of studying these cohorts is to delineate neuroendocrine measures that are linked to characteristics of infants that may predispose them to mental health problems. The subjects and their caretakers predispose them to mental health problems. The subjects and their caretakers will be assessed using salivary cortisol and a laboratory stress procedure (maternal separation and maternal still face) in an attempt to describe and explain the interaction of caregiver characteristics with infant regulatory features (sleeping, feeding, feeding, and crying) that define a construct of dysregulation. In addition, the study seeks to explore the establishment and predictability of circadian rhythms in children as an antecedent to stable basal cortisol levels indicative of a """"""""less reactive"""""""" stress LHPA axis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH059396-02
Application #
6468447
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2001-03-01
Project End
2002-02-28
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
$192,910
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Kuhlman, Kate R; Olson, Sheryl L; Lopez-Duran, Nestor L (2014) Predicting developmental changes in internalizing symptoms: examining the interplay between parenting and neuroendocrine stress reactivity. Dev Psychobiol 56:908-23
Mayer, Stefanie E; Abelson, James L; Lopez-Duran, Nestor L (2014) Effortful control and context interact in shaping neuroendocrine stress responses during childhood. Horm Behav 66:457-65
Lopez-Duran, Nestor L; Hajal, Nastassia J; Olson, Sheryl L et al. (2009) Individual differences in cortisol responses to fear and frustration during middle childhood. J Exp Child Psychol 103:285-95
Lopez-Duran, Nestor L; Olson, Sheryl L; Hajal, Nastassia J et al. (2009) Hypothalamic pituitary adrenal axis functioning in reactive and proactive aggression in children. J Abnorm Child Psychol 37:169-82
Maggs, Jennifer L; Schulenberg, John E (2005) Initiation and course of alcohol consumption among adolescents and young adults. Recent Dev Alcohol 17:29-47
Lopez, Nestor L; Vazquez, Delia M; Olson, Sheryl L (2004) An integrative approach to the neurophysiological substrates of social withdrawal and aggression. Dev Psychopathol 16:69-93
Schulenberg, John E; Sameroff, Arnold J; Cicchetti, Dante (2004) The transition to adulthood as a critical juncture in the course of psychopathology and mental health. Dev Psychopathol 16:799-806