Abstract

This project is designed to extend our understanding of glutamatergic function in schizophrenia by applying proton magnetic resonance spectroscopy (1H MRS) and functional magnetic resonance imaging (fMRI) methods. Specifically, we propose to assess superior temporal and dorsolateral prefrontal cortical (DLPFC) concentrations of N-acetyl-L- aspartate (NAA) using 1H MRS, as well as cortical activation during verbal fluency tasks before and after 8 weeks of treatment with D- cycloserine (DCS), partial NMDA receptor agonist, using fMRI. In addition, methods for the MRS detection and quantification of N-acetyl- aspartyl-glutamate (NAAG) will be developed and implemented using a new 4 Tesla MR scanner.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
1P50MH060450-01A1
Application #
6405546
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2000-07-21
Project End
2005-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Dickie, Erin W; Ameis, Stephanie H; Shahab, Saba et al. (2018) Personalized Intrinsic Network Topography Mapping and Functional Connectivity Deficits in Autism Spectrum Disorder. Biol Psychiatry 84:278-286
Di Martino, Adriana; O'Connor, David; Chen, Bosi et al. (2017) Enhancing studies of the connectome in autism using the autism brain imaging data exchange II. Sci Data 4:170010
Wolosker, Herman; Balu, Darrick T; Coyle, Joseph T (2016) The Rise and Fall of the d-Serine-Mediated Gliotransmission Hypothesis. Trends Neurosci 39:712-721
Balu, Darrick T; Li, Yan; Takagi, Shunsuke et al. (2016) An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia. Neuropsychopharmacology 41:2052-61
Coyle, Joseph T; Balu, Darrick T; Puhl, Matthew D et al. (2016) History of the Concept of Disconnectivity in Schizophrenia. Harv Rev Psychiatry 24:80-6
Takagi, Shunsuke; Balu, Darrick T; Coyle, Joseph T (2015) Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice. Schizophr Res 162:216-21
Alaerts, Kaat; Nayar, Kritika; Kelly, Clare et al. (2015) Age-related changes in intrinsic function of the superior temporal sulcus in autism spectrum disorders. Soc Cogn Affect Neurosci 10:1413-23
Konopaske, Glenn T; Coyle, Joseph T (2015) Possible compensatory mechanisms for glutamatergic disconnection found in the auditory cortex in schizophrenia. Biol Psychiatry 77:923-4
Valk, Sofie L; Di Martino, Adriana; Milham, Michael P et al. (2015) Multicenter mapping of structural network alterations in autism. Hum Brain Mapp 36:2364-73
Ishiwata, Sayuri; Umino, Asami; Balu, Darrick T et al. (2015) Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus. J Neural Transm (Vienna) 122:1099-103

Showing the most recent 10 out of 128 publications