The purpose of this core is to provide an experimental design, analytic, epidemiologic, and data management resource to the Conte Center. For data management roles in the administration of extant and new data files the core will provide a repository for the data in the Conte Center in a secured environment. Data will arrive from multiple sources on a multiple of media requiring sophisticated technology and software expertise to create the final relational database. From these permanent files, analytic files can be created for final analyses. In addition, the core will provide consultation in experimental design and data collection using epidemiological principles for clinical and experimental populations, and provide statistical assistance in the analysis and reporting the resulting data. Given the rich and complicated longitudinal nature of many of the clinical data bases, sophisticated statistical/epidemiologic techniques will be necessary to: (1) perform data reduction and imputation procedures, and (2) perform complex analysis of imaging, clinical data and animal studies. In addition to these roles, the core personnel will program and debug statistical and data management programs, explain statistical issues in design, provide statistical programming, explain results from programs, and assist in preparation and reporting of results of the analytic portions of papers. Finally, the statistician, data manager and data manager in this core will be available for consultation in analysis, experimental design, and power in formulating and honing research hypotheses into viable projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
1P50MH060451-01A2
Application #
6553550
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2001-09-01
Project End
2006-07-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Petyuk, Vladislav A; Chang, Rui; Ramirez-Restrepo, Manuel et al. (2018) The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target. Brain 141:2721-2739
Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384
Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738
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Mez, Jesse; Mukherjee, Shubhabrata; Thornton, Timothy et al. (2016) The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiol Aging 41:115-121
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-200.e20
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150
Jun, G; Ibrahim-Verbaas, C A; Vronskaya, M et al. (2016) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry 21:108-17
Jacobsen, Jacob Pr; Rudder, Meghan L; Roberts, Wendy et al. (2016) SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept. Neuropsychopharmacology 41:2324-34
Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-129

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