This project is central to the Conte center. All other projects are linked to this project in a conceptual and a practical sense. This project follows up on our findings that lesions disrupt the functioning of the mood circuit in elderly patients with depression. The project utilizes multimodal imaging Diffusion tensor imaging (DTI), magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) along with cognitive testing and genetics to study the connectivity and dysregulation of the mood circuit. Based on findings from our earlier work we evaluate the nature of the changes in the fiber tracts connecting amygdala, Orbital prefrontal cortex, dorsolateral prefrontal cortex, striatum and its relationship to neurocognitive changes. We evaluate whether glutamate is reduced in the anterior cingulate and orbital prefrontal cortex in patients with depression using MRS. In addition we evaluate changes in brain structure and function as it relates to serotonin transporter promoter region allelic variants. This project uses state of the art image processing and will lead to a greater understanding of the neuroanatomical substrates of depression.
| Petyuk, Vladislav A; Chang, Rui; Ramirez-Restrepo, Manuel et al. (2018) The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target. Brain 141:2721-2739 |
| Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384 |
| Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738 |
| Mez, Jesse; Mukherjee, Shubhabrata; Thornton, Timothy et al. (2016) The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiol Aging 41:115-121 |
| Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-200.e20 |
| Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150 |
| Jun, G; Ibrahim-Verbaas, C A; Vronskaya, M et al. (2016) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry 21:108-17 |
| Jacobsen, Jacob Pr; Rudder, Meghan L; Roberts, Wendy et al. (2016) SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept. Neuropsychopharmacology 41:2324-34 |
| Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-129 |
| Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43 |
Showing the most recent 10 out of 250 publications
