Core A coordinate the resources and facilities necessary for attaining the scientific mission of the CCNMD.? It has four complementary functions: 1. Administrative Coordination to CCNMD investigators, trainees and? personnel includes implementation of NIH, University and IRB guidelines of fiscal monitoring, allocation of? resources, progress reports, grant preparation, human subjects and animal protocols; review new? initiatives; provide liaison with University and Community; establish policies when indicated.? 2. Academic Coordination among CCNMD investigators, trainees and personnel includes communication? of findings across CCNMD laboratories; integration of educational activities, such as seminars and? presentations of speakers; liaison with neuroscience programs across campus and in other academic? settings; recruitment of highly qualified predoctoral and postdoctoral trainees. The CCNMD maintains a? comprehensive outreach program to the community that contributes to dissemination of information? regarding basic and clinical neuroscience research in schizophrenia through speakers in local, regional? and national meetings and in an open-house format, inviting the public to Penn. With the Data and Biostatistics Core and Projects,? this Core coordinates the Center's website, ensure access to data, research tools and biological material? generated by the Center, and facilitate interaction with the Advisory Board.? 3. Recruitment and Assessment for CCNMD human Subprojects (0001, 0002, 0007). Standardized procedures are applied? to participants with schizophrenia, family members and healthy people. This includes evaluation of medical,? neurological and psychiatric status, computerized neurocognitive measures and genotyping. The Core? provides systematic assessment of clinical history and presentation of individuals whose brains are? donated for postmortem research in Subproject 0007 and coordinates data transfer to Data and Biostatistics Core and Subprojects (0001, 0002, 0007, and 0010). The Coordination Core maintains a registry for future studies and integrative projects,? and provide training in clinical neuroscience assessment to graduate students, fellows and investigators in? the Center and collaborating programs.? 4. Allocation of participants to animal projects provides coordination of the protocols, tracking with the Data and Biostatistics Core? the flow of participants across Subprojects 0003, 0008, and 0009 and works closely with investigators and research? personnel in the animal projects to ensure that the scientific goals are met. This is done in parallel to the? human studies maintaining high level of integration across the Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
2P50MH064045-06
Application #
7162025
Study Section
Special Emphasis Panel (ZMH1-ERB-S (04))
Project Start
2006-07-01
Project End
2011-06-30
Budget Start
2006-09-15
Budget End
2007-07-31
Support Year
6
Fiscal Year
2006
Total Cost
$313,168
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
van Erp, Theo G M; Walton, Esther; Hibar, Derrek P et al. (2018) Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biol Psychiatry 84:644-654
Walton, E; Hibar, D P; van Erp, T G M et al. (2017) Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatr Scand 135:439-447
Barz, Claudia S; Bessaih, Thomas; Abel, Ted et al. (2016) Sensory encoding in Neuregulin 1 mutants. Brain Struct Funct 221:1067-81
Satterthwaite, Theodore D; Wolf, Daniel H; Calkins, Monica E et al. (2016) Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms. JAMA Psychiatry 73:515-24
Welle, Cristin G; Contreras, Diego (2016) Sensory-driven and spontaneous gamma oscillations engage distinct cortical circuitry. J Neurophysiol 115:1821-35
Satterthwaite, Theodore D; Connolly, John J; Ruparel, Kosha et al. (2016) The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth. Neuroimage 124:1115-9
Barz, Claudia S; Bessaih, Thomas; Abel, Ted et al. (2016) Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1. Brain Struct Funct 221:4383-4398
Collier, Azurii K; Wolf, Daniel H; Valdez, Jeffrey N et al. (2014) Comparison of auditory and visual oddball fMRI in schizophrenia. Schizophr Res 158:183-8
Robinson, John L; Molina-Porcel, Laura; Corrada, Maria M et al. (2014) Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old. Brain 137:2578-87
Larimore, Jennifer; Zlatic, Stephanie A; Gokhale, Avanti et al. (2014) Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes. J Biol Chem 289:14291-300

Showing the most recent 10 out of 118 publications