This project investigates the role of phonological representations during high level language comprehension. The research tests the hypothesis that sustained activation of phonological information, interacting with semantic information, forms a crucial part of sentence and discourse comprehension. The approach builds on earlier work within a connectionist computational modeling framework in which linguistic working memory is not viewed as separate from the language comprehension system but rather as emergent from comprehension and production processes. A better understanding of the role of phonological information in memory and sentence comprehension will contribute to research on patients with phonological impairments and also to an understanding of language comprehension processes more generally. There are four specific aims: 1) Assess the role of phonological information in sentence processing in behavioral studies of normal readers. We hypothesize that phonological information has several distinct functions in sentence comprehension, including supplementing semantic information in maintaining distinct representations of discourse referents, and providing a verbatim representation of word order information to aid parsing of complex structures. 2) Use functional magnetic resonance imaging (fMRI) during sentence processing and working memory tasks to investigate the extent to which phonological activation contributes to sentence processing. 3) Investigate the memory and sentence processing abilities of patients with phonological impairments. 4) Develop computational models addressing the role of phonology in sentence comprehension in both normal and impaired populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
1P50MH064445-01
Application #
6689483
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2002-09-20
Project End
2007-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Carnegie-Mellon University
Department
Type
DUNS #
052184116
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Criss, Amy H; Wheeler, Mark E; McClelland, James L (2013) A differentiation account of recognition memory: evidence from fMRI. J Cogn Neurosci 25:421-35
Gregoriou, Georgia G; Gotts, Stephen J; Desimone, Robert (2012) Cell-type-specific synchronization of neural activity in FEF with V4 during attention. Neuron 73:581-94
Gardner, Hannah E; Lambon Ralph, Matthew A; Dodds, Naomi et al. (2012) The differential contributions of pFC and temporo-parietal cortex to multimodal semantic control: exploring refractory effects in semantic aphasia. J Cogn Neurosci 24:778-93
Acheson, Daniel J; Macdonald, Maryellen C (2011) The Rhymes that the Reader Perused Confused the Meaning: Phonological Effects during On-line Sentence Comprehension. J Mem Lang 65:193-207
Jefferies, Elizabeth; Rogers, Timothy T; Ralph, Matthew A Lambon (2011) Premorbid expertise produces category-specific impairment in a domain-general semantic disorder. Neuropsychologia 49:3213-23
Hoffman, Paul; Jefferies, Elizabeth; Ralph, Matthew A Lambon (2011) Remembering 'zeal' but not 'thing': reverse frequency effects as a consequence of deregulated semantic processing. Neuropsychologia 49:580-4
Hoffman, Paul; Jefferies, Elizabeth; Ralph, Matthew A Lambon (2011) Explaining semantic short-term memory deficits: evidence for the critical role of semantic control. Neuropsychologia 49:368-81
Corbett, Faye; Jefferies, Elizabeth; Ralph, Matthew A Lambon (2011) Deregulated semantic cognition follows prefrontal and temporo-parietal damage: evidence from the impact of task constraint on nonverbal object use. J Cogn Neurosci 23:1125-35
Woollams, Anna M; Silani, Giorgia; Okada, Kayoko et al. (2011) Word or word-like? Dissociating orthographic typicality from lexicality in the left occipito-temporal cortex. J Cogn Neurosci 23:992-1002
Ingvalson, Erin M; McClelland, James L; Holt, Lori L (2011) Predicting Native English-Like Performance by Native Japanese Speakers. J Phon 39:571-584

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