; PROJECT 2: ATTENTION AND DUAL-TASK INTERFERENCE We continue to use a translational behavioral science strategy to bring paradigms with greater analytic power to the study of attention in schizophrenia. The collaboration between Dr. Pashler of UCSD and clinical researchers Drs. Nuechterlein and Subotnik of UCLA has yielded strong evidence in favor of specific models of structural processing bottlenecks in divided attention in schizophrenia. Beyond this, sites of marked structural processing bottlenecks in schizophrenia have been isolated in response selection processes and response production processes. Thus, while perceptual encoding proceeds normally without causing dual-task interference in schizophrenia patients, response selection processes and response production (motoric) processes in one task markedly interfere with doing another task. While many aspects of dual-task interference are abnormal across phases of illness, some component of an abnormally severe processing bottleneck tend to progress in severity from prodromal to later phases of schizophrenia. Motoric interference also predicts later work functioning independently from memory and social cognition deficits, suggesting that it has a distinctive role. In the next phase ofthis project, several new steps are proposed. First, to integrate findings in the memory project with the findings ofthis attention project, we will examine whether declarative memory processes interfere with other simultaneous processing in a way that involves a particularly severe structural processing bottleneck in schizophrenia. Second, we will extend the findings ofthis project to situations that involve motivated decisions with hedonic consequences, rather than only simple pre-designated response selections. Third, we will examine further whether the contribution of motor processes to attentional dysfunction and functional outcome is distinct from the contribution of memory processes. Finally, we will examine the extent to which indicators of particular processing bottlenecks in schizophrenia serve as contributors to functional capacity and through it contribute to everyday functional leve

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH066286-09
Application #
8497723
Study Section
Special Emphasis Panel (ZMH1-ERB-N)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
9
Fiscal Year
2013
Total Cost
$157,981
Indirect Cost
$52,380
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Lee, Junghee; Nuechterlein, Keith H; Knowlton, Barbara J et al. (2018) Episodic Memory for Dynamic Social Interaction Across Phase of Illness in Schizophrenia. Schizophr Bull 44:620-630
Velthorst, Eva; Meyer, Eric C; Giuliano, Anthony J et al. (2018) Neurocognitive profiles in the prodrome to psychosis in NAPLS-1. Schizophr Res :
Chen, Qiaolin; Sugar, Catherine A; Weiss, Robert E (2018) A Bayesian confirmatory factor model for multivariate observations in the form of two-way tables of data. Stat Med 37:1696-1710
Hamilton, Holly K; Williams, Terrance J; Ventura, Joseph et al. (2018) Clinical and Cognitive Significance of Auditory Sensory Processing Deficits in Schizophrenia. Am J Psychiatry 175:275-283
Clayson, Peter E; Kern, Robert S; Nuechterlein, Keith H et al. (2018) Social vs. non-social measures of learning potential for predicting community functioning across phase of illness in schizophrenia. Schizophr Res :
Hampton, Joya N; Trotman, Hanan D; Addington, Jean et al. (2018) The relation of atypical antipsychotic use and stress with weight in individuals at clinical high risk for psychosis. Stress Health 34:591-600
Kline, Emily R; Seidman, Larry J; Cornblatt, Barbara A et al. (2018) Depression and clinical high-risk states: Baseline presentation of depressed vs. non-depressed participants in the NAPLS-2 cohort. Schizophr Res 192:357-363
Fernandez, Vindia G; Asarnow, Robert; Narr, Katherine L et al. (2018) Temporal lobe thickness and verbal memory in first-degree relatives of individuals with schizophrenia. Schizophr Res 199:221-225
Woodberry, Kristen A; Seidman, Larry J; Bryant, Caitlin et al. (2018) Treatment Precedes Positive Symptoms in North American Adolescent and Young Adult Clinical High Risk Cohort. J Clin Child Adolesc Psychol 47:69-78
Grazioplene, Rachael G; Bearden, Carrie E; Subotnik, Kenneth L et al. (2018) Connectivity-enhanced diffusion analysis reveals white matter density disruptions in first episode and chronic schizophrenia. Neuroimage Clin 18:608-616

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