The Mouse Genetics Core is responsible for collaborating in the design and execution of experiments that use genetically-defined mouse strains to model the genetic and phenotypic aspects of schizophrenia that the Center has identified in human subjects. Acra7 (acetylcholine receptor alpha7) is the mouse equivalent of the CHRNA7 (CHolinergic Receptor Nicotinic alpha7) gene for the alpha7 nicotinic receptor that the Center will be focusing on in their human work. The experiments rely on acra7 knockout strains and a spontaneously occurring mutation in the inbred DBA/2 mouse strain in the acra7 gene. Dr. Sherry Leonard (Project 0001) proposes to use acra7 knockouts as a model to help interpret results from her human post mortem brain microarray assays. Dr. Diego Restrepo (Project 0002) is currently examining differences in alpha7 nicotinic receptor expression in the olfactory bulb and olfactory behavioral differences between DBA/2 and C3H mice, as a model for the differences he will be examining in schizophrenics. Dr. Robert Freedman (Project 0004) will use congenic mouse strains (the DBA/2 acra7 locus on a C3H background) to investigate the developmental pharmacology of sensory gating abnormalities. He will also use various acra7 null mutant strains to determine the mechanisms of action of perinatal choline treatment. The director of the core, Dr. Allan Collins, is director of the mouse behavioral genetics facility at the Institute for Behavioral Genetics and a NIDA-funded investigator whose principal research interest, the genetic determination of the response to nicotine, formed the scientific basis of the animal model experiments of this application.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH068582-05
Application #
7643230
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
5
Fiscal Year
2008
Total Cost
$163,760
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
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Hutchison, Amanda K; Kelsay, Kimberly; Talmi, Ayelet et al. (2016) Thought Disorder in Preschool Children with Attention Deficit/Hyperactivity Disorder (ADHD). Child Psychiatry Hum Dev 47:618-26
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Pellegrino, Laurel; Ross, Randal G; Hunter, Sharon K (2013) In Six-month-old Infants, Prenatal Exposure to Maternal Anxiety is Associated with Less Developed Smooth Pursuit Eye Movements: An Initial Study. Int Neuropsychiatr Dis J 1:89-103
Sparks, Tierney A; Hunter, Sharon K; Backman, Toni L et al. (2012) Maternal parenting stress and mothers' reports of their infants' mastery motivation. Infant Behav Dev 35:167-73
Stephens, Sarah H; Franks, Alexis; Berger, Ralph et al. (2012) Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. Psychiatr Genet 22:1-14
Davalos, Deana B; Rojas, Donald C; Tregellas, Jason R (2011) Temporal processing in schizophrenia: effects of task-difficulty on behavioral discrimination and neuronal responses. Schizophr Res 127:123-30
Hunter, Sharon K; Kisley, Michael A; McCarthy, Lizbeth et al. (2011) Diminished cerebral inhibition in neonates associated with risk factors for schizophrenia: parental psychosis, maternal depression, and nicotine use. Schizophr Bull 37:1200-8
Hellier, Jennifer L; Arevalo, Nicole L; Blatner, Megan J et al. (2010) Olfactory discrimination varies in mice with different levels of ?7-nicotinic acetylcholine receptor expression. Brain Res 1358:140-50

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