Abstract

Our understanding of the neural mechanisms of memory has been advanced by the characterization of neural activity in behaving animals. The research described in the Projects 2-3 depends crucially on sophisticated devices for simultaneous recording of the activity of multiple neurons and field potentials at multiple sites. For some aims, we require that these devices give us the flexibility to sample hippocampal neurons with regular spacing along the septotemporal axis. For the last aim of Project 3, we require the ability to deliver patterned electrical stimulation to neurons at flexibly chosen sites. Development and fabrication of these devices will be accomplished by establishment of a dedicated facility and personnel who will design and construct multichannel electrode arrays, as well as headstages for preliminary amplification and stimulation of neural activity at multiple sites. The Engineering Core will also serve as a general electronics and mechanics shop for Center personnel and students. Engineering Core personnel will train Center members in safe use of Core equipment and serve as a source of technical advice.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH071702-04
Application #
7942807
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
4
Fiscal Year
2009
Total Cost
$236,410
Indirect Cost

  Institution

Name
Boston University
Department
Type
DUNS #
049435266
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Kraus, Benjamin J; Brandon, Mark P; Robinson 2nd, Robert J et al. (2015) During Running in Place, Grid Cells Integrate Elapsed Time and Distance Run. Neuron 88:578-89
Brown, Thackery I; Hasselmo, Michael E; Stern, Chantal E (2014) A high-resolution study of hippocampal and medial temporal lobe correlates of spatial context and prospective overlapping route memory. Hippocampus 24:819-39
Prerau, Michael J; Lipton, Paul A; Eichenbaum, Howard B et al. (2014) Characterizing context-dependent differential firing activity in the hippocampus and entorhinal cortex. Hippocampus 24:476-92
Brown, Thackery I; Whiteman, Andrew S; Aselcioglu, Irem et al. (2014) Structural differences in hippocampal and prefrontal gray matter volume support flexible context-dependent navigation ability. J Neurosci 34:2314-20
Brown, Thackery I; Stern, Chantal E (2014) Contributions of medial temporal lobe and striatal memory systems to learning and retrieving overlapping spatial memories. Cereb Cortex 24:1906-22
Kraus, Benjamin J; Robinson 2nd, Robert J; White, John A et al. (2013) Hippocampal ""time cells"": time versus path integration. Neuron 78:1090-101
Ross, Robert S; LoPresti, Matthew L; Schon, Karin et al. (2013) Role of the hippocampus and orbitofrontal cortex during the disambiguation of social cues in working memory. Cogn Affect Behav Neurosci 13:900-15
Erdem, U?ur M; Hasselmo, Michael (2012) A goal-directed spatial navigation model using forward trajectory planning based on grid cells. Eur J Neurosci 35:916-31
Brown, Thackery I; Ross, Robert S; Tobyne, Sean M et al. (2012) Cooperative interactions between hippocampal and striatal systems support flexible navigation. Neuroimage 60:1316-30
Lepage, Kyle Q; Macdonald, Christopher J; Eichenbaum, Howard et al. (2012) The statistical analysis of partially confounded covariates important to neural spiking. J Neurosci Methods 205:295-304

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