This application requests five years of support to establish a multidisciplinary research center at UCLA entitled """"""""Translational Research to Enhance Cognitive Control (TRECC)"""""""" as a part of the NIMH Centers for Intervention Development and Applied Research (CIDAR) program. Utilizing our expertise in animal models, cognitive neuroscience, neuroimaging, neuropsychopharmacology, behavioral therapies, genetics, we will advance the science of treatment approaches for the cognitive deficits common to a large number of neuropsychiatric disorders afflicting children and adolescents. We will especially focus on pediatric disorders with prominent problems of cognitive control, particularly the often overlapping disorders of Attention-Deficit/Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS), due to their unmet treatment needs, prevalence, morbidity and comorbidity, and shared pathophysiologic features. Ultimately, we believe our work will be relevant to an even larger group of children with other conditions, but who share the dimension of significant deficits in behavior regulation, cognitive processing, and judgement. The central theme of the UCLA CIDAR TRECC Center is the understanding and modeling of the mechanisms underlying cognitive deficits shared by a range of developmental psychopathologies leading to the development and testing of targeted and more efficacious treatments to enhance cognition in these conditions. Our focus is in direct response to the PA's call for the development of treatment approaches for clinical targets of illnesses which clearly influence morbidity but which are not sufficiently remediated by extant treatments. Impaired cognition in developmental psychopathologies clearly serves as a major determinant of functioning and long-term outcome. There is a great need to recognize cognitive enhancement in pediatric disorders as a primary treatment target and to develop and test new treatment approaches. If successful, such efforts hold the promise of significantly improving the long-term outcome of individuals with these disabilities. The UCLA CIDAR Center will approach this theme through the completion of four interacting multi-level studies in animals and humans, utilizing the resources developed and made available through three research cores supported by the CIDAR Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH077248-04
Application #
7665300
Study Section
Special Emphasis Panel (ZMH1-ERB-A (01))
Program Officer
Grabb, Margaret C
Project Start
2006-09-01
Project End
2011-07-31
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
4
Fiscal Year
2009
Total Cost
$1,813,309
Indirect Cost
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Sturm, Alexandra; Rozenman, Michelle; Piacentini, John C et al. (2018) The Effect of Neurocognitive Function on Math Computation in Pediatric ADHD: Moderating Influences of Anxious Perfectionism and Gender. Child Psychiatry Hum Dev 49:822-832
Sturm, Alexandra; Rozenman, Michelle; Chang, Susanna et al. (2018) Are the components of social reciprocity transdiagnostic across pediatric neurodevelopmental disorders? Evidence for common and disorder-specific social impairments. Psychiatry Res 264:119-123
McGuire, Joseph F; Piacentini, John; Storch, Eric A et al. (2018) A multicenter examination and strategic revisions of the Yale Global Tic Severity Scale. Neurology 90:e1711-e1719
Sabb, Fred W; Hellemann, Gerhard; Allen, Nicholas B et al. (2018) Enhanced switching and familial susceptibility for psychosis. Brain Behav 8:e00988
Loo, Sandra K; McGough, James J; McCracken, James T et al. (2018) Parsing heterogeneity in attention-deficit hyperactivity disorder using EEG-based subgroups. J Child Psychol Psychiatry 59:223-231
Greene, D J; Williams Iii, A C; Koller, J M et al. (2017) Brain structure in pediatric Tourette syndrome. Mol Psychiatry 22:972-980
Loo, Sandra K; Bilder, Robert M; Cho, Alexander L et al. (2016) Effects of d-Methylphenidate, Guanfacine, and Their Combination on Electroencephalogram Resting State Spectral Power in Attention-Deficit/Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry 55:674-682.e1
Bilder, Robert M; Loo, Sandra K; McGough, James J et al. (2016) Cognitive Effects of Stimulant, Guanfacine, and Combined Treatment in Child and Adolescent Attention-Deficit/Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry 55:667-73
McCracken, James T; McGough, James J; Loo, Sandra K et al. (2016) Combined Stimulant and Guanfacine Administration in Attention-Deficit/Hyperactivity Disorder: A Controlled, Comparative Study. J Am Acad Child Adolesc Psychiatry 55:657-666.e1
Lenartowicz, Agatha; Delorme, Arnaud; Walshaw, Patricia D et al. (2014) Electroencephalography correlates of spatial working memory deficits in attention-deficit/hyperactivity disorder: vigilance, encoding, and maintenance. J Neurosci 34:1171-82

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