The auditory cortex exhibits a broad range of response modes spanning from phasic, single spike or binary responses to tonic, multi-spike, sustained random firing sequences per stimulus. The goal of this project is to determine the character of response variability of different types of auditory cortical neurons in the awaken squirrel monkey. This will allow us to assess the potential role and influence of variability on neuronal encoding, and its impact on behavioral performance and to compare the results to other response modalities. To achieve this, it is necessary to obtain simultaneous estimates of neural and behavioral performance in the awaken animal. Response variability will be assessed under three conditions, in the passive listening animal to serve as a baseline, in the animal actively involved in a behavioral sound discrimination task to assess attention effects, and in animals that are highly trained to assess the effects of learning on the expression of response variability. In conjunction with the other projects, these studies will contribute to establishing general rules, across sensory and motor systems, of the nature and role of response variability in the generation of behavior.
| Chaisanguanthum, Kris S; Shen, Helen H; Sabes, Philip N (2017) Neural Representation and Causal Models in Motor Cortex. J Neurosci 37:3413-3424 |
| Cheung, Steven W; Atencio, Craig A; Levy, Eliott R J et al. (2017) Anisomorphic cortical reorganization in asymmetric sensorineural hearing loss. J Neurophysiol 118:932-948 |
| Yazdan-Shahmorad, Azadeh; Diaz-Botia, Camilo; Hanson, Timothy L et al. (2016) A Large-Scale Interface for Optogenetic Stimulation and Recording in Nonhuman Primates. Neuron 89:927-39 |
| Zhou, Miou; Greenhill, Stuart; Huang, Shan et al. (2016) CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory. Elife 5: |
| Malone, Brian J; Beitel, Ralph E; Vollmer, Maike et al. (2015) Modulation-frequency-specific adaptation in awake auditory cortex. J Neurosci 35:5904-16 |
| Ravits, John (2014) Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis. Exp Neurol 262 Pt B:121-6 |
| Chaisanguanthum, Kris S; Shen, Helen H; Sabes, Philip N (2014) Motor variability arises from a slow random walk in neural state. J Neurosci 34:12071-80 |
| Atencio, Craig A; Shih, Jonathan Y; Schreiner, Christoph E et al. (2014) Primary auditory cortical responses to electrical stimulation of the thalamus. J Neurophysiol 111:1077-87 |
| Schreiner, Christoph E; Polley, Daniel B (2014) Auditory map plasticity: diversity in causes and consequences. Curr Opin Neurobiol 24:143-56 |
| Malone, Brian J; Beitel, Ralph E; Vollmer, Maike et al. (2013) Spectral context affects temporal processing in awake auditory cortex. J Neurosci 33:9431-50 |
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