Little is known about the mechanisms of change in cognitive behavioral therapy (CBT) for anxious youth,potentially because most treatment outcome studies have focused only on changes in diagnostic status andsymptoms, rather than using a multi-method approach to understand changes across multiple systemsassociated with recovery. Using a transdisciplinary approach, this core will provide an integrated structure forexamining changes in symptoms, behavior in family and peer contexts, sleep, and brain reactivity tocognitive and emotional information processing tasks among anxious children before, during, and after CBTand CCT. These data will be used as the basis for analyses across all three of the primary projects.Specifically, this core describes the following assessments. Before and after treatment, participants willcomplete measures of clinical status, symptoms, affective style, and parent-child interactions using ratingscales, self-report measures, and behavioral observations. Genetic data will also be acquired. Participantswill complete cognitive and affective information processing measures during fMRI and concurrent pupildilation/eyetracking assessment, as well as event-related potential (ERP) assessment. On a biweekly basisthroughout treatment, participants will complete self-report ratings of symptomatology, pupildilation/eyetracking assessments, and a home based Ecological Momentary Assessment and sleepactigraphy protocol. This core integrates and oversees the assessment methodologies for all projects. Ofparticular importance, methods are provided for creating composite summary indices for each primarydomain of assessment, for use in each project and in cross-project analyses, via methods developed in Core3.Having these methods centralized in a single core, with a single project coordinator, and an integrativemeasurement approach is essential for this CIDAR mechanism. Centralizing the administration of theseassessments will 1) contribute to a better understanding of how these assessments fit together, 2) facilitatelater integration of analyses and results across projects, and 3) increase efficiency and decrease participantburden by integrating assessments in a convenient and planful manner.
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