The Data Management and Biostatistics Core (DMB) provides consultation and technical support for study design, data collection, monitoring study data integrity, statistical analysis and analytic interpretation for Center projects and cores. The DMB has been organized to address the challenges of conducting multiple projects simultaneously. The data from the six projects and three cores is voluminous and comes from a wide range of sources. The variety and volume of data represent enormous potential for the Center, but also underscores the importance of a comprehensive data management methodology and quality biostatistical support to achieve the Centers aims. DMB Core members have substantial expertise in these areas and will provide comprehensive support services to the Center projects and cores. A core devoted to biostatistics and data management will enhance the process of data collection, insure that data is properly managed; data integrity is maintained and statistical analyses and the interpretation of study results are accurately conducted, allowing all investigators to be more fully productive in fulfilling the substantive research aims put forth by each core and project. Jim Robinson will be the Principal investigator of the DMB Core. Mr. Robinson has over 35 years of experience in clinical research data management, informatics and biostatistics. He is the Director of Innovative Clinical Research Solutions at the Nathan Kline Institute and Director of Clinical Research Informatics at the New York University Langone Medical Center Department of Psychiatry. The Data Management Core has four primary goals: 1) to implement and integrate a centralized data management methodology, 2) to provide active statistical consultation and support in the design, analyses and interpretation of the Centers studies including publishing the results in professional journals and disseminating results for public consumption, 3) to stimulate the exchange of ideas and knowledge between investigators from different Center projects;and 4. to facilitate cross-projects studies and develop new statistical methodologies. The Data Management Core wi|l also provide full database management to clinical trials being conduction in Project 6, will integrate database information across other clinical projects (Projects 1 and 5 and Core B), will support DNA databanking being conducted by Core B, will maintain the Center website and will support Center data sharing operations.

Public Health Relevance

Schizophrenia is a major mental disorder. Neurocognitive dysfunction is a core component of schizophrenia and a major determinant of poor long-term outcome. This project is part of a Center application to determine brain mechanisms underlying neurocognitive dysfunction in schizophrenia with particular emphasis on sensory processing dysfunction. This Core will provide necessary database and statistical support to ensure successful completion of Center aims.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
New York
United States
Zip Code
Corcoran, Cheryl M; Stoops, Anastasia; Lee, Migyung et al. (2018) Developmental trajectory of mismatch negativity and visual event-related potentials in healthy controls: Implications for neurodevelopmental vs. neurodegenerative models of schizophrenia. Schizophr Res 191:101-108
Lee, Migyung; Balla, Andrea; Sershen, Henry et al. (2018) Rodent Mismatch Negativity/theta Neuro-Oscillatory Response as a Translational Neurophysiological Biomarker for N-Methyl-D-Aspartate Receptor-Based New Treatment Development in Schizophrenia. Neuropsychopharmacology 43:571-582
Brucato, Gary; Appelbaum, Paul S; Masucci, Michael D et al. (2018) Prevalence and phenomenology of violent ideation and behavior among 200 young people at clinical high-risk for psychosis: an emerging model of violence and psychotic illness. Neuropsychopharmacology :
Kantrowitz, Joshua T; Epstein, Michael L; Lee, Migyung et al. (2018) Improvement in mismatch negativity generation during d-serine treatment in schizophrenia: Correlation with symptoms. Schizophr Res 191:70-79
Potvin, Olivier; Dieumegarde, Louis; Duchesne, Simon et al. (2017) Freesurfer cortical normative data for adults using Desikan-Killiany-Tourville and ex vivo protocols. Neuroimage 156:43-64
Brucato, G; Masucci, M D; Arndt, L Y et al. (2017) Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort. Psychol Med 47:1923-1935
Potvin, Olivier; Dieumegarde, Louis; Duchesne, Simon et al. (2017) Normative morphometric data for cerebral cortical areas over the lifetime of the adult human brain. Neuroimage 156:315-339
Poe, Sarah-Lucy; Brucato, Gary; Bruno, Nicolina et al. (2017) Sleep disturbances in individuals at clinical high risk for psychosis. Psychiatry Res 249:240-243
Zhao, Jizheng; Li, Mintong; Zhang, Yi et al. (2017) Intrinsic brain subsystem associated with dietary restraint, disinhibition and hunger: an fMRI study. Brain Imaging Behav 11:264-277
Kantrowitz, Joshua T; Nolan, Karen A; Epstein, Michael L et al. (2017) Neurophysiological Effects of Bitopertin in Schizophrenia. J Clin Psychopharmacol 37:447-451

Showing the most recent 10 out of 96 publications