? PROJECT 4 How we respond to negative events, regulate our responses to them, and later remember them ? plays a central role in mood and/or anxiety disorders, such as depression, and can lead individuals to engage in self- destructive behaviors, including suicide. As such, a critical question for research is what psychological and neural mechanisms generate our initial response to an aversive event, encode that event into memory, and enable us to regulate our response to it. In the current funding period, we began addressing these issues by examining the relationship between MDD, suicide risk, and the generation and regulation of responses to normatively negative and positive stimuli. In this renewal, three factors guide our continued focus on negative emotional reactivity and regulation as well as a new focus on memory. First, in the current funding period we found that responses to aversive stimuli were most strongly related to clinically relevant variables collected in Ps 1, 3 and 5. Second, to capture idosyncratically self-relevant negative responses that may be relevant to suicide risk, we developed a novel variant of our emotion regulation task that involved recollecting unpleasant autobiographical memories and in pilot data found that it was sensitive to MDD vs. control differences in amygdala and hippocampal function. Third, chronic stress is known to impact structural integrity of the PFC and hippocampus via HPA axis activation and neuroinflammation, and postmortem P1 data has identified such changes in suicide decedents. Given these data, in this proposal we focus on studying how MDD and suicide risk are related to PFC, amygdala and hippocampal systems, in the context of:
(Aim 1) recollecting and regulating responses to aversive autobiographical memories, (Aim 2) generating enduring negative emotional states that may carry over to subsequent neutral experiences and color memory for them, and understanding how individual differences in clinical and biological variables collected under Projects 3 and 5 relate to data collected under Aims 1 and 2.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH090964-08
Application #
9959473
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2013-07-19
Project End
2023-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
8
Fiscal Year
2020
Total Cost
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Boldrini, Maura; Fulmore, Camille A; Tartt, Alexandria N et al. (2018) Human Hippocampal Neurogenesis Persists throughout Aging. Cell Stem Cell 22:589-599.e5
Youssef, Mariam M; Underwood, Mark D; Huang, Yung-Yu et al. (2018) Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide. Int J Neuropsychopharmacol 21:528-538
Abreu, L N; Oquendo, M A; Galfavy, H et al. (2018) Are comorbid anxiety disorders a risk factor for suicide attempts in patients with mood disorders? A two-year prospective study. Eur Psychiatry 47:19-24
Rizk, Mina M; Rubin-Falcone, Harry; Lin, Xuejing et al. (2018) Gray matter volumetric study of major depression and suicidal behavior. Psychiatry Res Neuroimaging 283:16-23
Daray, Federico M; Mann, J John; Sublette, M Elizabeth (2018) How lipids may affect risk for suicidal behavior. J Psychiatr Res 104:16-23
Rizk, Mina M; Galfalvy, Hanga; Singh, Tanya et al. (2018) Toward subtyping of suicidality: Brief suicidal ideation is associated with greater stress response. J Affect Disord 230:87-92
Rubin-Falcone, Harry; Zanderigo, Francesca; Thapa-Chhetry, Binod et al. (2018) Pattern recognition of magnetic resonance imaging-based gray matter volume measurements classifies bipolar disorder and major depressive disorder. J Affect Disord 227:498-505
Chaudhury, Sadia R; Galfalvy, Hanga; Biggs, Emily et al. (2017) Affect in response to stressors and coping strategies: an ecological momentary assessment study of borderline personality disorder. Borderline Personal Disord Emot Dysregul 4:8
Fitzgerald, Megan L; Kassir, Suham A; Underwood, Mark D et al. (2017) Dysregulation of Striatal Dopamine Receptor Binding in Suicide. Neuropsychopharmacology 42:974-982
Ganança, Licinia; Galfalvy, Hanga C; Oquendo, Maria A et al. (2017) Lipid correlates of antidepressant response to omega-3 polyunsaturated fatty acid supplementation: A pilot study. Prostaglandins Leukot Essent Fatty Acids 119:38-44

Showing the most recent 10 out of 49 publications