The purpose of the GENETICS CORE is to provide for genetic analysis of genomic DNA samples collected by the Research PROJECTS. Centralized genotyping of human and primate samples will maximize our efficiency by utilizing consistent methods for carrying out and interpreting genotyping data. This CORE will have four primary goals, which are to a) extract genomic DNA from peripheral blood or saliva from individual PROJECTS;b) to genotype the serotonin transporter promoter repeat polymorphism 5-HTTLRR in human and primate samples;c) to genotype single nucleotide polymorphisrns (SNPs) and a repeat polymorphism from five serotonin-related genes in human samples;and dj to genotype DNA variants showing genetic association in a replication sample of human samples. The CORE will work closely with the PROJECTS and with the biostatistics and imaging COREs to allow efficient sharing and analysis of genotypic data.
Evidence suggests that the serotonergic system plays an important role in human brain development. We anticipate that our work will facilitate genetic aspects of this research that is being carried using a variety of experimental systems.
|Lugo-Candelas, Claudia; Cha, Jiook; Hong, Susie et al. (2018) Associations Between Brain Structure and Connectivity in Infants and Exposure to Selective Serotonin Reuptake Inhibitors During Pregnancy. JAMA Pediatr 172:525-533|
|Hao, Xuejun; Talati, Ardesheer; Shankman, Stewart A et al. (2017) Stability of Cortical Thinning in Persons at Increased Familial Risk for Major Depressive Disorder Across 8 Years. Biol Psychiatry Cogn Neurosci Neuroimaging 2:619-625|
|Anderson, Micheline R; Miller, Lisa; Wickramaratne, Priya et al. (2017) Genetic Correlates of Spirituality/Religion and Depression: A Study in Offspring and Grandchildren at High and Low Familial Risk for Depression. Spiritual Clin Pract (Wash D C ) 4:43-63|
|Talati, Ardesheer; Wickramaratne, Priya J; Wesselhoeft, Rikke et al. (2017) Prenatal tobacco exposure, birthweight, and offspring psychopathology. Psychiatry Res 252:346-352|
|Gingrich, Jay A; Malm, Heli; Ansorge, Mark S et al. (2017) New Insights into How Serotonin Selective Reuptake Inhibitors Shape the Developing Brain. Birth Defects Res 109:924-932|
|Svob, Connie; Liu, Jie; Wickramaratne, Priya et al. (2017) Neuroanatomical correlates of familial risk-for-depression and religiosity/spirituality. Spiritual Clin Pract (Wash D C ) 4:32-42|
|Desai, Jay; Huo, Yuankai; Wang, Zhishun et al. (2017) Reduced perfusion in Broca's area in developmental stuttering. Hum Brain Mapp 38:1865-1874|
|Talati, Ardesheer; Odgerel, Zagaa; Wickramaratne, Priya J et al. (2017) Associations between serotonin transporter and behavioral traits and diagnoses related to anxiety. Psychiatry Res 253:211-219|
|Weissman, Myrna M; Berry, Obianuju O; Warner, Virginia et al. (2016) A 30-Year Study of 3 Generations at High Risk and Low Risk for Depression. JAMA Psychiatry 73:970-7|
|Posner, J; Cha, J; Roy, A K et al. (2016) Alterations in amygdala-prefrontal circuits in infants exposed to prenatal maternal depression. Transl Psychiatry 6:e935|
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