Abstract

This Core provides expertise in biostatistics and database management across Projects that meet the needs of animal and human studies. The Core will offer resources for study design, statistical analysis, database management, data checking, entry, verification, transfer, and protocol management. This is a critical part of the Center and essential for high quality integrative research. Standard and specialized statistical and graphics software is available. Projects are linked by protocols for data transfer and statistical consultation is assimilated into design. Core B interacts with Core A to coordinate and track human and animal research participants, contributing to all Projects and to career development.

Public Health Relevance

The expertise and services provided by this Core are essential for achieving high quality research in the Conte Center. The Core will ensure proper study design, smooth operations of the database, access to computing facilities, data security and data analysis. It will also provide education to trainees in experimental design and statistics.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
4P50MH096891-05
Application #
9118377
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Khan, Atlas; Liu, Qian; Wang, Kai (2018) iMEGES: integrated mental-disorder GEnome score by deep neural network for prioritizing the susceptibility genes for mental disorders in personal genomes. BMC Bioinformatics 19:501
Amiri, Anahita; Coppola, Gianfilippo; Scuderi, Soraya et al. (2018) Transcriptome and epigenome landscape of human cortical development modeled in organoids. Science 362:
Barzilay, Ran; White, Lauren K; Calkins, Monica E et al. (2018) Sex-Specific Association Between High Traumatic Stress Exposure and Social Cognitive Functioning in Youths. Biol Psychiatry Cogn Neurosci Neuroimaging 3:860-867
Forrest, Alexandra D; Bang, Jakyung; Featherstone, Robert E et al. (2018) Pyramidal cell-selective GluN1 knockout causes impairments in salience attribution and related EEG activity. Exp Brain Res 236:837-846
Grunfeld, Itamar S; Likhtik, Ekaterina (2018) Mixed selectivity encoding and action selection in the prefrontal cortex during threat assessment. Curr Opin Neurobiol 49:108-115
Wang, Daifeng; Liu, Shuang; Warrell, Jonathan et al. (2018) Comprehensive functional genomic resource and integrative model for the human brain. Science 362:
Thomas, Michael L; Brown, Gregory G; Gur, Ruben C et al. (2018) A signal detection-item response theory model for evaluating neuropsychological measures. J Clin Exp Neuropsychol 40:745-760
Pehlivanova, Marieta; Wolf, Daniel H; Sotiras, Aristeidis et al. (2018) Diminished Cortical Thickness is Associated with Impulsive Choice in Adolescence. J Neurosci :
Gandal, Michael J; Zhang, Pan; Hadjimichael, Evi et al. (2018) Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science 362:
Agrawal, A; Chou, Y-L; Carey, C E et al. (2018) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry 23:1293-1302

Showing the most recent 10 out of 87 publications