Two key principles define the core conceptual framework of our Conte Center. First, most sensory input is actively acquired by a motor and/or attentional sampling routine; e.g., rather than staring blankly and hoping that something will ?fall? into our gaze, we Actively Scan the visible environment with eye movements. Even when fixating, we can actively (albeit covertly) scan the environment by shifting attention. Corresponding ?scanning? of the auditory environment uses the more covert attentional sampling strategy, but is no less active. As a result, Active Sensing (i.e., strategic, goal-driven sampling of inputs) is ?predictive? in that, it is guided by the subject's expectations (theories, models), accumulated through species' evolution, and refined by individuals' experience. Its central tenet is that sensing and perceiving can be fully understood only in the context of subjects' ongoing, goal-directed information-gathering activities. Second, neuronal oscillatory dynamics are critical mechanistic components of normal brain operation. Neuronal oscillations reflect rhythmic fluctuations of neuron ensembles between high and low excitability states. Mounting evidence indicates that such rhythmic activity is essential to normal brain operations, and that its disruption contributes to neuropsychiatric disorders. The idea that Active Sensing incorporates neuronal rhythms as fundamental instruments of operation represents an ongoing paradigm shift in systems neuroscience. Our Center is unified by support Cores and a set of mechanistic (linking) hypotheses concerning the ?instrumental? functions of neuronal rhythms at local and network scales. The Center integrates electrocorticographic (ECoG) studies in humans with intracortical recordings in monkeys and computational modeling.
Our Specific Aims are:
AIM 1 ? Exploit ECoG's strengths of distributed sampling and direct human brain recording to define dynamical circuits of top-down control and coordination across cortical areas in Active Sensing. To gain a sample size appropriate for our purposes, we will pool subjects across 5 surgical epilepsy centers using a common set of Active Sensing tasks, and a common data format.
AIM 2 ? Use recordings in nonhuman primates to elucidate and extend ECoG findings in humans. Laminar field potential (FP), current source density (CSD) and multiunit activity (MUA) profiles, along with single unit recordings will be obtained from monkeys performing tasks identical to those studied in humans.
AIM 3 ? Develop iterative interactions between computational and empirical studies of circuit dynamics at local (cell assembly) and global (brain network) levels. Tracking specific neuronal dynamics from the global-network level in humans down to the cellular and cell ensemble levels in monkeys will yield novel and unique insights into mechanisms of active brain operation. Statistical and Computational modeling will allow rapid exploration of possibilities suggested by ECoG and related multielectrode studies in monkeys, and will help in building accurately representing and integrating our findings across local and global scales.

Public Health Relevance

A rich body of evidence suggests that normal cognitive processes depend on neuronal rhythms, and that their disruption contributes to cognitive, emotional, and behavioral dysfunction in neuropsychiatric conditions including schizophrenia, autism and attention deficit disorder. The Center's investigators have each worked on this problem for a number of years. Interlocking our individual strengths and leveraging the resources of the Center vastly increases the reach and potential impact of our research efforts.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-L (01))
Program Officer
Rossi, Andrew
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Schools of Medicine
New York
United States
Zip Code
Milham, Michael P; Ai, Lei; Koo, Bonhwang et al. (2018) An Open Resource for Non-human Primate Imaging. Neuron 100:61-74.e2
Xu, Ting; Falchier, Arnaud; Sullivan, Elinor L et al. (2018) Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo. Cell Rep 23:429-441
Swift, J R; Coon, W G; Guger, C et al. (2018) Passive functional mapping of receptive language areas using electrocorticographic signals. Clin Neurophysiol 129:2517-2524
Fiebelkorn, Ian C; Pinsk, Mark A; Kastner, Sabine (2018) A Dynamic Interplay within the Frontoparietal Network Underlies Rhythmic Spatial Attention. Neuron 99:842-853.e8
Bonnefond, Mathilde; Kastner, Sabine; Jensen, Ole (2017) Communication between Brain Areas Based on Nested Oscillations. eNeuro 4:
Holdgraf, Christopher R; Rieger, Jochem W; Micheli, Cristiano et al. (2017) Encoding and Decoding Models in Cognitive Electrophysiology. Front Syst Neurosci 11:61
Halassa, Michael M; Kastner, Sabine (2017) Thalamic functions in distributed cognitive control. Nat Neurosci 20:1669-1679
Popov, Tzvetan; Kastner, Sabine; Jensen, Ole (2017) FEF-Controlled Alpha Delay Activity Precedes Stimulus-Induced Gamma-Band Activity in Visual Cortex. J Neurosci 37:4117-4127