The Yale Epilepsy Research Center Program Project is organized as a widely based investigational effort into mechanisms of epileptic seizures and their control. A consortium of 25 scientists from various disciplines have joined together to study experimental and clinical aspects of epilepsy. The ultimate aim of these studies is to discern factors responsible for the occurrence, frequency, and effects of seizures, and how they can be controlled. Animal experimental, human clinical and neuropathological studies are oriented toward an understanding of basic physiological and neurochemical alterations responsible for seizures as well as a development of pharmacological and surgical methods effective for treatment and control of seizures. The specific scientific components of this research program are: - Cellular Actions of Antiepileptic Drugs on Hippocampal Neurons - Microdialysis of Intracerebral Extracellular Fluid in Epilepsy Patients - Pharmacology of Antiepileptic Drugs Using Microdialysis in Epilepsy Patients - Evaluation of SPECT Benzodiazepine Receptor Imaging and MRI to Localize a Seizure Focus - Molecular Neuroanatomic Analyses of Epileptiform Human Temporal Lobe Tissue - Neurophysiological Studies of Human Epileptic Hippocampus - NMR Spectroscopic Analyses of Human Cerebrum and Synaptosomes - Extracellular pH Responses in Mammalian CNS

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
2P50NS006208-31A2
Application #
2383850
Study Section
Special Emphasis Panel (ZNS1-SRB-K (J1))
Program Officer
Jacobs, Margaret
Project Start
1986-09-01
Project End
2002-03-31
Budget Start
1997-04-01
Budget End
1998-03-31
Support Year
31
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Yale University
Department
Neurology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Ransom, Christopher B; Wu, Yuanming; Richerson, George B (2010) Postdepolarization potentiation of GABAA receptors: a novel mechanism regulating tonic conductance in hippocampal neurons. J Neurosci 30:7672-84
Radtke, C; Spies, M; Sasaki, M et al. (2007) Demyelinating diseases and potential repair strategies. Int J Dev Neurosci 25:149-53
Wu, Yuanming; Wang, Wengang; Diez-Sampedro, Ana et al. (2007) Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1. Neuron 56:851-65
Tokuno, Hajime A; Bradberry, Charles W; Everill, Brian et al. (2004) Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves. Brain Res 996:159-67
Everill, B; Cummins, T R; Waxman, S G et al. (2001) Sodium currents of large (Abeta-type) adult cutaneous afferent dorsal root ganglion neurons display rapid recovery from inactivation before and after axotomy. Neuroscience 106:161-9
Everill, B; Kocsis, J D (2000) Nerve growth factor maintains potassium conductance after nerve injury in adult cutaneous afferent dorsal root ganglion neurons. Neuroscience 100:417-22
Yee, J M; Agulian, S; Kocsis, J D (1998) Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve. Epilepsy Res 29:195-200
Honmou, O; Kocsis, J D; Richerson, G B (1995) Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro. Epilepsy Res 20:193-202
Honmou, O; Oyelese, A A; Kocsis, J D (1995) The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis. Brain Res 692:273-7
Utzschneider, D A; Rand, M N; Waxman, S G et al. (1994) Nuclear and cytoplasmic Ca2+ signals in developing rat dorsal root ganglion neurons studied in excised tissue. Brain Res 635:231-7

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