Abstract

We propose to maintain and refine magnetic resonance (MR) methods for functional brain imaging (fMRI), anatomical imaging, diffusion tensor imaging (DT-MRI, including imaging of isotropic diffusion and diffusion anisotropy), and DT-MRI based tracking of neuronal fiber pathways. This core will provide a consistent and reliable set of tools throughout the Program, Project Grant period for study of brain function and structure in the normal and ischemic human brain, and for characterizing ischemic brain lesions. These tools will facilitate comparison of MR data within and across experiments and across the three Projects. During the grant period, fMRI, anatomical MRI, DT-MRI, and diffusion tracking methods will also be developed for the 3T head-only MRI scanner to utilize the higher performance of this system. These methods will be made available to the Projects for use in experiments having specialized needs when methods are fully tested and performance improvements are documented.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
2P50NS006833-34
Application #
6316057
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
1976-12-01
Project End
2005-02-28
Budget Start
Budget End
Support Year
34
Fiscal Year
2000
Total Cost
$288,253
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Goyal, Manu S; Vlassenko, Andrei G; Blazey, Tyler M et al. (2017) Loss of Brain Aerobic Glycolysis in Normal Human Aging. Cell Metab 26:353-360.e3
Shannon, Benjamin J; Vaishnavi, Sanjeev Neil; Vlassenko, Andrei G et al. (2016) Brain aerobic glycolysis and motor adaptation learning. Proc Natl Acad Sci U S A 113:E3782-91
Wig, Gagan S; Laumann, Timothy O; Cohen, Alexander L et al. (2014) Parcellating an individual subject's cortical and subcortical brain structures using snowball sampling of resting-state correlations. Cereb Cortex 24:2036-54
Goyal, Manu S; Hawrylycz, Michael; Miller, Jeremy A et al. (2014) Aerobic glycolysis in the human brain is associated with development and neotenous gene expression. Cell Metab 19:49-57
Powers, William J (2014) William M. Feinberg award for excellence in clinical stroke: hemodynamics and stroke risk in carotid artery occlusion. Stroke 45:3123-8
Glasser, Matthew F; Goyal, Manu S; Preuss, Todd M et al. (2014) Trends and properties of human cerebral cortex: correlations with cortical myelin content. Neuroimage 93 Pt 2:165-75
Power, Jonathan D; Mitra, Anish; Laumann, Timothy O et al. (2014) Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage 84:320-41
Duchek, Janet M; Balota, David A; Thomas, Jewell B et al. (2013) Relationship between Stroop performance and resting state functional connectivity in cognitively normal older adults. Neuropsychology 27:516-28
Wang, Liang; Brier, Matthew R; Snyder, Abraham Z et al. (2013) Cerebrospinal fluid A?42, phosphorylated Tau181, and resting-state functional connectivity. JAMA Neurol 70:1242-8
Shannon, B J; Dosenbach, R A; Su, Y et al. (2013) Morning-evening variation in human brain metabolism and memory circuits. J Neurophysiol 109:1444-56

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