Abstract

The long term goal of this project is to understand the neural basis of functional recovery after focal brain injury. Neuroimaging (functional magnetic resonance imaging, fMRI, and positron emission tomography, PET) and methods will be used to study the recovery of aphasia after focal damage to the left frontal lobe. In particular, we will assess the relative contribution to recovery of tissue surrounding the infarction, and/or of homologous regions in the contralateral hemisphere. These findings will have implications for the design of neurobiologically- oriented strategies of rehabilitation, and the evaluation of therapies aimed at salvaging brain tissue around the core of a stroke.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS006833-36
Application #
6573414
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2002-03-01
Project End
2003-02-28
Budget Start
Budget End
Support Year
36
Fiscal Year
2002
Total Cost
$288,253
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Goyal, Manu S; Vlassenko, Andrei G; Blazey, Tyler M et al. (2017) Loss of Brain Aerobic Glycolysis in Normal Human Aging. Cell Metab 26:353-360.e3
Shannon, Benjamin J; Vaishnavi, Sanjeev Neil; Vlassenko, Andrei G et al. (2016) Brain aerobic glycolysis and motor adaptation learning. Proc Natl Acad Sci U S A 113:E3782-91
Wig, Gagan S; Laumann, Timothy O; Cohen, Alexander L et al. (2014) Parcellating an individual subject's cortical and subcortical brain structures using snowball sampling of resting-state correlations. Cereb Cortex 24:2036-54
Goyal, Manu S; Hawrylycz, Michael; Miller, Jeremy A et al. (2014) Aerobic glycolysis in the human brain is associated with development and neotenous gene expression. Cell Metab 19:49-57
Powers, William J (2014) William M. Feinberg award for excellence in clinical stroke: hemodynamics and stroke risk in carotid artery occlusion. Stroke 45:3123-8
Glasser, Matthew F; Goyal, Manu S; Preuss, Todd M et al. (2014) Trends and properties of human cerebral cortex: correlations with cortical myelin content. Neuroimage 93 Pt 2:165-75
Power, Jonathan D; Mitra, Anish; Laumann, Timothy O et al. (2014) Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage 84:320-41
Duchek, Janet M; Balota, David A; Thomas, Jewell B et al. (2013) Relationship between Stroop performance and resting state functional connectivity in cognitively normal older adults. Neuropsychology 27:516-28
Wang, Liang; Brier, Matthew R; Snyder, Abraham Z et al. (2013) Cerebrospinal fluid A?42, phosphorylated Tau181, and resting-state functional connectivity. JAMA Neurol 70:1242-8
Shannon, B J; Dosenbach, R A; Su, Y et al. (2013) Morning-evening variation in human brain metabolism and memory circuits. J Neurophysiol 109:1444-56

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