The diagnosis of DAI in humans remains presumptive because no current diagnostic method has the resolution to detect axonal damage or to distinguish axonal damage from other types of traumatic white matter abnormalities (TWMA). This project uses a combination of magnetic transfer imaging (MTI) and magnetic resonance spectroscopy (MRS) to detect TWMA and to differentiate types of TWMA based on a combination of their structural and biochemical characteristics. Since both of these methods are quantitative, they will be combined in a lesion severity index that describes the severity of individual TWMA and in a global severity score that describes the severity of all TWMA in a patient. These indices will be followed temporally in human head injured patients to categorize TWMA, to determine the natural history of several types of TWMA, to correlate them to conventional measures of injury severity and outcome, and to correlate them to similar TWMA verified histopathologically in Project 1.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Nariai, Hiroki; Duberstein, Susan; Shinnar, Shlomo (2018) Treatment of Epileptic Encephalopathies: Current State of the Art. J Child Neurol 33:41-54
Nariai, Hiroki; Beal, Jules; Galanopoulou, Aristea S et al. (2017) Scalp EEG Ictal gamma and beta activity during infantile spasms: Evidence of focality. Epilepsia 58:882-892
Tomasevic, Gregor; Laurer, Helmut L; Mattiasson, Gustav et al. (2012) Delayed neuromotor recovery and increased memory acquisition dysfunction following experimental brain trauma in mice lacking the DNA repair gene XPA. J Neurosurg 116:1368-78
Browne, Kevin D; Chen, Xiao-Han; Meaney, David F et al. (2011) Mild traumatic brain injury and diffuse axonal injury in swine. J Neurotrauma 28:1747-55
Tomasevic, Gregor; Raghupathi, Ramesh; Scherbel, Uwe et al. (2010) Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice. J Neurosci Res 88:3414-23
Hånell, Anders; Clausen, Fredrik; Björk, Maria et al. (2010) Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice. J Neurotrauma 27:1297-309
Marklund, N; Morales, D; Clausen, F et al. (2009) Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice. Neuroscience 163:540-51
Marklund, Niklas; Bareyre, Florence M; Royo, Nicolas C et al. (2007) Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression. J Neurosurg 107:844-53
Keck, Carrie A; Thompson, Hilaire J; Pitkanen, Asla et al. (2007) The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury. Restor Neurol Neurosci 25:77-90
Serbest, Gulyeter; Burkhardt, Matthew F; Siman, Robert et al. (2007) Temporal profiles of cytoskeletal protein loss following traumatic axonal injury in mice. Neurochem Res 32:2006-14

Showing the most recent 10 out of 71 publications