Abstract

This Core serves two principal functions for the Center: 1. Injury Production Activities are centralized for creating repeatable injuries of varying severity. The models used for these projects involve focal axonal injury in the guinea pig optic nerve, experimental DAI in the minipig, fluid and solid percussion in the rat, and cortical contusion in the rat. The single injury production facility will assure quality control and comparability of the injuries produced. 2. Biomechanics Research will be conducted to improve the fidelity of the various injury models and to better understand their relationships to human head injury.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS008803-26
Application #
6243409
Study Section
Project Start
1997-08-01
Project End
1998-07-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
26
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Nariai, Hiroki; Duberstein, Susan; Shinnar, Shlomo (2018) Treatment of Epileptic Encephalopathies: Current State of the Art. J Child Neurol 33:41-54
Nariai, Hiroki; Beal, Jules; Galanopoulou, Aristea S et al. (2017) Scalp EEG Ictal gamma and beta activity during infantile spasms: Evidence of focality. Epilepsia 58:882-892
Tomasevic, Gregor; Laurer, Helmut L; Mattiasson, Gustav et al. (2012) Delayed neuromotor recovery and increased memory acquisition dysfunction following experimental brain trauma in mice lacking the DNA repair gene XPA. J Neurosurg 116:1368-78
Browne, Kevin D; Chen, Xiao-Han; Meaney, David F et al. (2011) Mild traumatic brain injury and diffuse axonal injury in swine. J Neurotrauma 28:1747-55
Tomasevic, Gregor; Raghupathi, Ramesh; Scherbel, Uwe et al. (2010) Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice. J Neurosci Res 88:3414-23
Hånell, Anders; Clausen, Fredrik; Björk, Maria et al. (2010) Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice. J Neurotrauma 27:1297-309
Marklund, N; Morales, D; Clausen, F et al. (2009) Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice. Neuroscience 163:540-51
Marklund, Niklas; Bareyre, Florence M; Royo, Nicolas C et al. (2007) Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression. J Neurosurg 107:844-53
Keck, Carrie A; Thompson, Hilaire J; Pitkanen, Asla et al. (2007) The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury. Restor Neurol Neurosci 25:77-90
Serbest, Gulyeter; Burkhardt, Matthew F; Siman, Robert et al. (2007) Temporal profiles of cytoskeletal protein loss following traumatic axonal injury in mice. Neurochem Res 32:2006-14

Showing the most recent 10 out of 71 publications