The objectives of this Core project are (1) to provide centralized support for all animal model studies in this Program and (2) to establish a new scientific direction in the Program which will focus on defining parameters and mechanisms of tolerance and rejection of transplanted dopamine neurons and adrenal medullary cells. Core support will include specialized maintenance of barrier sustained normal and cyclosporin A-immunosuppressed euthymic and athymic Nude rats with fetal allogeneic and xenogeneic (human) brain , Schwann cell and chromaffin cell transplants. Other core services to program investigators will include gross and histo-pathological analyses and serological surveillance of experimental animals, consultation on laboratory animal genetics and modeling.
| Bowenkamp, K E; David, D; Lapchak, P L et al. (1996) 6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor. Exp Brain Res 111:1-7 |
| Freed, C R (1986) The trained circling rat and in vivo electrochemistry: a behavioral model and a measurement method to study the dynamic role of dopamine in movement. Ann N Y Acad Sci 473:188-99 |
| Freed, C R; Yamamoto, B K (1985) Regional brain dopamine metabolism: a marker for the speed, direction, and posture of moving animals. Science 229:62-5 |
