The goal of the clinical investigative core is to accomplish meaningful clinical investigative research while at the same time integrating the highest quality 'state of the art' patient care. The function of the core will be to provide clinical, technical expertise and appropriate facilities to help implement the three clinical protocols of this program project. Many of the tests, investigations, and gathering of data will occur at a time when the patient is the least stable and most care is required. This core centralizes the investigative team which will remain on 24-hour call throughout the year and provide the expertise necessary to carry out the studies involving cerebral microdialysis, cerebral blood flow, magnetic resonance brain water imaging and intracranial pressure dynamics. The clinical research team, will include a neurosurgical head injury fellow, trained at MCV in all aspects of head injury management, who will assume responsibility for coordinating the studies with ongoing patient care. Each clinical research fellow will be assigned one of three clinical projects and serve as back up for the remaining two. Expertise in neuroradiology for scheduling and on-site conduct of imaging procedures, and technical refinement CTCBF, CTCBV, and MRI methods will also be provided by the Core. In addition, the core will provide access to the Neurosurgical computing center for on-line computer monitoring of all physiologic parameters monitored in the ICU as well as data management expertise to analyze data essential to all clinical projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS012587-20
Application #
3738197
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Kleindienst, Andrea; Dunbar, Jana G; Glisson, Renee et al. (2013) The role of vasopressin V1A receptors in cytotoxic brain edema formation following brain injury. Acta Neurochir (Wien) 155:151-64
Brophy, Gretchen M; Mazzeo, Anna Teresa; Brar, Satjit et al. (2013) Exposure of cyclosporin A in whole blood, cerebral spinal fluid, and brain extracellular fluid dialysate in adults with traumatic brain injury. J Neurotrauma 30:1484-9
Prieto, Ruth; Tavazzi, Barbara; Taya, Keisuke et al. (2011) Brain energy depletion in a rodent model of diffuse traumatic brain injury is not prevented with administration of sodium lactate. Brain Res 1404:39-49
Fazzina, Giovanna; Amorini, Angela M; Marmarou, Christina R et al. (2010) The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat. J Neurotrauma 27:453-61
Mazzeo, Anna Teresa; Brophy, Gretchen M; Gilman, Charlotte B et al. (2009) Safety and tolerability of cyclosporin a in severe traumatic brain injury patients: results from a prospective randomized trial. J Neurotrauma 26:2195-206
Fabricius, Martin; Fuhr, Susanne; Willumsen, Lisette et al. (2008) Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain. Clin Neurophysiol 119:1973-84
Mazzeo, Anna Teresa; Alves, Oscar Luis; Gilman, Charlotte B et al. (2008) Brain metabolic and hemodynamic effects of cyclosporin A after human severe traumatic brain injury: a microdialysis study. Acta Neurochir (Wien) 150:1019-31;discussion 1031
Lu, J; Marmarou, A; Choi, S et al. (2005) Mortality from traumatic brain injury. Acta Neurochir Suppl 95:281-5
Tavazzi, Barbara; Signoretti, Stefano; Lazzarino, Giuseppe et al. (2005) Cerebral oxidative stress and depression of energy metabolism correlate with severity of diffuse brain injury in rats. Neurosurgery 56:582-9; discussion 582-9
Signoretti, Stefano; Marmarou, Anthony; Tavazzi, Barbara et al. (2004) The protective effect of cyclosporin A upon N-acetylaspartate and mitochondrial dysfunction following experimental diffuse traumatic brain injury. J Neurotrauma 21:1154-67

Showing the most recent 10 out of 12 publications