Abstract

We propose to test hypotheses important to the understanding of several cerebral disorders which are characterized by regional dysfunctions involving altered cerebral perfusion, metabolism, amino acid utilization, or neurotransmitter processes. To accomplish this positron emission tomography (PET) will be applied to quantify these local cerebral measures. New PET markers will be introduced, in addition to those already available, to permit in vivo determination of neurotransmitter processes associated with dopaminergic, noradrenergic, serotonergic, cholinergic, glutaminergic, and GABAergic systems. This will be accomplished by a cohesive development process for selection of new radiotracers, preparation in positron-emitter labeled form, evaluation in small animals and then in primates, development of mathematical models, and assessment of radiotracer pharmacokinetics in human PET studies. Clinical research projects are supported by scientific cores responsible for cyclotron, chemistry, tomography, data analysis and administrative functions. It is expected that these efforts will enhance understanding and improve diagnosis and management of patients with disorders of motor function, Huntington's disease, Parkinson's disease, brain tumors, and epilepsy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS015655-13
Application #
3107697
Study Section
Special Emphasis Panel (SRC (05))
Project Start
1979-12-01
Project End
1994-11-30
Budget Start
1991-12-01
Budget End
1992-11-30
Support Year
13
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Albin, Roger L; Fisher-Hubbard, Amanda; Shanmugasundaram, Krithika et al. (2015) Post-Mortem evaluation of amyloid-dopamine terminal positron emission tomography dementia classifications. Ann Neurol 78:824-30
Soileau, Michael J; Persad, Carol; Taylor, Jennifer et al. (2014) Caregiver burden in patients with Parkinson disease undergoing deep brain stimulation: an exploratory analysis. J Parkinsons Dis 4:517-21
Shao, Xia; Fawaz, Maria V; Jang, Keunsam et al. (2014) Ethanolic carbon-11 chemistry: the introduction of green radiochemistry. Appl Radiat Isot 89:125-9
Younes, Laurent; Ratnanather, J Tilak; Brown, Timothy et al. (2014) Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis. Hum Brain Mapp 35:792-809
Kilbourn, Michael R (2013) PET radioligands for the vesicular transporters for monoamines and acetylcholine. J Labelled Comp Radiopharm 56:167-71
Shao, Xia; Schnau, Paul L; Fawaz, Maria V et al. (2013) Enhanced radiosyntheses of [¹¹C]raclopride and [¹¹C]DASB using ethanolic loop chemistry. Nucl Med Biol 40:109-16
Bohnen, Nicolaas I; Müller, Martijn L T M (2013) In vivo neurochemical imaging of olfactory dysfunction in Parkinson's disease. J Neural Transm (Vienna) 120:571-6
Meisler, Miriam H; Grant, Adrienne E; Jones, Julie M et al. (2013) C9ORF72 expansion in a family with bipolar disorder. Bipolar Disord 15:326-32
Shao, Xia; Hoareau, Raphaël; Hockley, Brian G et al. (2011) Highlighting the Versatility of the Tracerlab Synthesis Modules. Part 1: Fully Automated Production of [F]Labelled Radiopharmaceuticals using a Tracerlab FX(FN). J Labelled Comp Radiopharm 54:292-307
Chen-Plotkin, Alice S; Martinez-Lage, Maria; Sleiman, Patrick M A et al. (2011) Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Arch Neurol 68:488-97

Showing the most recent 10 out of 27 publications