Abstract

The purpose of the behavioral Core is to evaluate the functional status of neural circuitry following traumatic brain injury in rats and mice, by quantitatively assessing sensorimotor and cognitive behavioral endpoints including seizures. Paradigms are designed to assess neurobehavioral deficits associated with fluid percussive TBI in rats, and controlled cortical impact in mice, and to evaluate, when possible, the relation between neurobehavioral endpoints and neuropathological, and neurophysiological markers. The tests of sensorimotor integration and cognition used in the core are have been demonstrated to be sensitive to insults produced by these TBI models, which, at moderate to severe levels of injury severity, produce overt pathology in the parietotemporal cortex, hippocampus, thalamus, and white matter.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS030291-17
Application #
8113453
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
17
Fiscal Year
2010
Total Cost
$150,775
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Type
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146

  Publications

Dixon, Kirsty J; Turbic, Alisa; Turnley, Ann M et al. (2017) Explant Methodology for Analyzing Neuroblast Migration. Bio Protoc 7:
Dixon, Kirsty J; Mier, Jose; Gajavelli, Shyam et al. (2016) EphrinB3 restricts endogenous neural stem cell migration after traumatic brain injury. Stem Cell Res 17:504-513
Dietrich, W Dalton; Bramlett, Helen M (2016) Therapeutic hypothermia and targeted temperature management in traumatic brain injury: Clinical challenges for successful translation. Brain Res 1640:94-103
Assis-Nascimento, Poincyane; Umland, Oliver; Cepero, Maria L et al. (2016) A flow cytometric approach to analyzing mature and progenitor endothelial cells following traumatic brain injury. J Neurosci Methods 263:57-67
Perez, Enmanuel J; Cepero, Maria L; Perez, Sebastian U et al. (2016) EphB3 signaling propagates synaptic dysfunction in the traumatic injured brain. Neurobiol Dis 94:73-84
Bramlett, Helen M; Dietrich, W Dalton (2015) Long-Term Consequences of Traumatic Brain Injury: Current Status of Potential Mechanisms of Injury and Neurological Outcomes. J Neurotrauma 32:1834-48
Blaya, Meghan O; Tsoulfas, Pantelis; Bramlett, Helen M et al. (2015) Neural progenitor cell transplantation promotes neuroprotection, enhances hippocampal neurogenesis, and improves cognitive outcomes after traumatic brain injury. Exp Neurol 264:67-81
Luo, Tianfei; Roman, Philip; Liu, Chunli et al. (2015) Upregulation of the GEF-H1 pathway after transient cerebral ischemia. Exp Neurol 263:306-13
Sun, Xin; Crawford, Robert; Liu, Chunli et al. (2015) Development-dependent regulation of molecular chaperones after hypoxia-ischemia. Neurobiol Dis 82:123-131
Dixon, Kirsty J; Theus, Michelle H; Nelersa, Claudiu M et al. (2015) Endogenous neural stem/progenitor cells stabilize the cortical microenvironment after traumatic brain injury. J Neurotrauma 32:753-64

Showing the most recent 10 out of 169 publications