The overall goal of project 3 is to explore cardiovascular control mechanisms in human autonomic disorders. Our focus during this cycle will be to determine if the Postural Orthostatic Tachycardia Syndrome (POTS) is associated with fundamental alterations in vasoconstrictor function at rest and during exercise. Our major hypotheses are that a) adrenergic vasoconstriction is blunted in POTS, b) cardiac output, but not blood pressure, will rise normally during exercise in patients with POTS, and c) sympathetic restraint of blood flow to active muscles will be absent in POTS. Together these impairments will evoke excessive reflex increases in heart rate during orthostatic stress or dynamic exercise in patients with POTS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS032352-15
Application #
7892377
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
15
Fiscal Year
2009
Total Cost
$248,388
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
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