Abstract

The overall goal of project 3 is to explore cardiovascular control mechanisms in human autonomic disorders. Our focus during this cycle will be to determine if the Postural Orthostatic Tachycardia Syndrome (POTS) is associated with fundamental alterations in vasoconstrictor function at rest and during exercise. Our major hypotheses are that a) adrenergic vasoconstriction is blunted in POTS, b) cardiac output, but not blood pressure, will rise normally during exercise in patients with POTS, and c) sympathetic restraint of blood flow to active muscles will be absent in POTS. Together these impairments will evoke excessive reflex increases in heart rate during orthostatic stress or dynamic exercise in patients with POTS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS032352-15
Application #
7892377
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
15
Fiscal Year
2009
Total Cost
$248,388
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Coon, Elizabeth A; Low, Phillip A (2017) Pure autonomic failure without alpha-synuclein pathology: an evolving understanding of a heterogeneous disease. Clin Auton Res 27:67-68
Limberg, Jacqueline K; Johnson, Blair D; Holbein, Walter W et al. (2016) Interindividual variability in the dose-specific effect of dopamine on carotid chemoreceptor sensitivity to hypoxia. J Appl Physiol (1985) 120:138-47
Wehrwein, Erica A; Limberg, Jacqueline K; Taylor, Jennifer L et al. (2015) Effect of bilateral carotid body resection on the counterregulatory response to hypoglycaemia in humans. Exp Physiol 100:69-78
Moffett, Kristin; Crosson, Bruce; Spence, Jeffrey S et al. (2015) Word-finding impairment in veterans of the 1991 Persian Gulf War. Brain Cogn 98:65-73
Limberg, Jacqueline K; Dube, Simmi; Kuijpers, Myrthe et al. (2015) Effect of hypoxia on heart rate variability and baroreflex sensitivity during hypoglycemia in type 1 diabetes mellitus. Clin Auton Res 25:243-50
Bharucha, Adil E; Kudva, Yogish; Basu, Ananda et al. (2015) Relationship between glycemic control and gastric emptying in poorly controlled type 2 diabetes. Clin Gastroenterol Hepatol 13:466-476.e1
Piccione, Ezequiel A; Sletten, David M; Staff, Nathan P et al. (2015) Autonomic system and amyotrophic lateral sclerosis. Muscle Nerve 51:676-9
Figueroa, Juan J; Singer, Wolfgang; Sandroni, Paola et al. (2015) Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults with orthostatic hypotension. Arch Phys Med Rehabil 96:505-10
Limberg, Jacqueline K; Taylor, Jennifer L; Mozer, Michael T et al. (2015) Effect of bilateral carotid body resection on cardiac baroreflex control of blood pressure during hypoglycemia. Hypertension 65:1365-71
Limberg, Jacqueline K; Farni, Kathryn E; Taylor, Jennifer L et al. (2014) Autonomic control during acute hypoglycemia in type 1 diabetes mellitus. Clin Auton Res 24:275-83

Showing the most recent 10 out of 66 publications