The Headache Research Center (HRC) is justified by the major health, social and economic problem of the migraine disorder which affects 17.6% of women and 6% of males in the United States. The HRC will provide the opportunity for focused and longitudinal research studies of headache, the commonest human malady. The overall goal of this proposal is to investigate the cause, mechanisms, and consequences of migraine. The concept is proposed that migraine is primarily a brain response to transient shifts of physiology whether systemic or in the brain, which modify the threshold for an attack. The underlying hypothesis is that the threshold for migraine is the state of polarization of cellular membranes in certain brain regions or neuronal systems. Project 1 is a population-based epidemiological study to substantiate and expand upon preliminary observations that migraine is associated with psychiatric co-morbidity particularly major depressive disorder and anxiety disorder. Project 2 uses a clinic and population based epidemiological approach to substantiate and expand upon preliminary observations that the prevalence of antiphospholipid antibodies in migraine is increased. Project 3 uses 31/Phosphorous magnetic resonance spectroscopy to measure brain energy metabolism and magnesium based on the hypothesis that migraine is associated with a disorder of mitochondrial oxidative phosphorylation, possibly secondary to magnesium deficiency. Project 4 uses magnetoencephalography to explore the mechanisms of the migraine attack based on the hypothesis that the aura of migraine is initiated by neuronal depolarization followed by spread of a depolarizing wave and suppression of neuronal function. The center is supported by an Administrative and Recruitment Core. Novel strategies are applied in the recruitment of subjects from a population base for epidemiological and clinical investigational studies. A Biostatistics Core assists and consults in the management and analysis of scientific data.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
1P50NS032399-01A1
Application #
2270567
Study Section
Special Emphasis Panel (SRC (01))
Project Start
1995-08-01
Project End
2000-07-31
Budget Start
1995-08-01
Budget End
1996-07-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Henry Ford Health System
Department
Neurology
Type
Schools of Medicine
DUNS #
073134603
City
Detroit
State
MI
Country
United States
Zip Code
48202
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Schultz, Lonni R; Peterson, Edward L; Breslau, Naomi (2002) Graphing survival curve estimates for time-dependent covariates. Int J Methods Psychiatr Res 11:68-74
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Breslau, N; Schultz, L R; Stewart, W F et al. (2001) Headache types and panic disorder: directionality and specificity. Neurology 56:350-4
Bowyer, S M; Aurora, K S; Moran, J E et al. (2001) Magnetoencephalographic fields from patients with spontaneous and induced migraine aura. Ann Neurol 50:582-7
Mulleners, W M; Aurora, S K; Chronicle, E P et al. (2001) Self-reported photophobic symptoms in migraineurs and controls are reliable and predict diagnostic category accurately. Headache 41:31-9

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