This training component of the Center of Excellence for Parkinson's Disease (PD) will be interdigitated with the current training program directed by Professor Francine at McLean and Harvard Medical School. This training grant has been exceptionally successful over the years and contains four cornerstones in its teaching. 1) Advanced Topics Lecture Series: This is the lecture series, a weekly presentation by an expert in Neuroscience covering topics such as functional anatomy and physiology, genetics, etc. (see attached). To this series, we will add several lectures including the genetics of PD, symptomatology of PD, pathology of PD and novel treatments for PD. The lectures for these are provided in the personnel section, with Cvs. 2) Lectures and Communications Skills: In this module, the fellows receive training to give seminars (one seminar per 6 months). They are critiqued by other fellows in the training program and by the course directors, Drs. Francine Benes and Ole Isacson. They are also supported by individual training sessions, prior to giving clinical rounds or presentations at scientific conferences. 3) Grantsmanship: The Principal investigators take their latest funded grants explaining structure and strategy for presenting their ideas and experiments. The fellows are also asked to write their own grant, specifically specific aims and abstract parts, and make outlines for the other sections of an R01 grant. 4) Clinical Case Studies: In module 4, fellows are exposed to videotapes of interviews from a range of neurodegenerative and psychiatric diseases. We will provide videotapes of PD patients. Clinical treatment studies, including pallidotomy and neural transplantation will also be used in this educational module.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
3P50NS039793-03S1
Application #
6499660
Study Section
Special Emphasis Panel (ZNS1)
Project Start
2001-08-01
Project End
2002-07-31
Budget Start
Budget End
Support Year
3
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Mc Lean Hospital (Belmont, MA)
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02478
Wang, Xin; Li, Nuomin; Xiong, Nian et al. (2017) Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease. Mol Neurobiol 54:2878-2888
Xiong, Nian; Li, Nuomin; Martin, Eden et al. (2016) hVMAT2: A Target of Individualized Medication for Parkinson's Disease. Neurotherapeutics 13:623-34
Hallett, Penelope J; Deleidi, Michela; Astradsson, Arnar et al. (2015) Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell 16:269-74
Hallett, Penelope J; Cooper, Oliver; Sadi, Damaso et al. (2014) Long-term health of dopaminergic neuron transplants in Parkinson's disease patients. Cell Rep 7:1755-61
Lindvall, Olle; Barker, Roger A; Brüstle, Oliver et al. (2012) Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell 10:151-5
Cooper, Oliver; Hallett, Penny; Isacson, Ole (2012) Using stem cells and iPS cells to discover new treatments for Parkinson's disease. Parkinsonism Relat Disord 18 Suppl 1:S14-6
Hallett, Penelope J; McLean, Jesse R; Kartunen, Andrew et al. (2012) ýý-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits. Neurobiol Dis 47:258-67
McLean, Jesse R; Hallett, Penelope J; Cooper, Oliver et al. (2012) Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression. Mol Cell Neurosci 49:230-9
Deleidi, Michela; Isacson, Ole (2012) Viral and inflammatory triggers of neurodegenerative diseases. Sci Transl Med 4:121ps3
Deleidi, Michela; Cooper, Oliver; Hargus, Gunnar et al. (2011) Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons. PLoS One 6:e19926

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