The patient access and administrative core is primarily designed to coordinate all research, educational, andadministrative activities within the SPOTRIAS. A second goal of this core is to monitor the evaluation andtreatment of acute stroke patients by the Greater Cincinnati/Northern Kentucky Stroke Team at 12participating regional SPOTRIAS hospitals in Greater Cincinnati/Northern Kentucky. Specific goals include:1. Direct and coordinate the administrative activities of the SPOTRIAS including preparation of progress ofall projects and cores. In addition, core personnel will prepare progress reports and monitor of financialexpenditures for the three projects coordinated by UC SPOTRIAS Center and four cores.2. Coordinate all educational and meeting activities of SPOTRIAS participants including meetings andtelephone calls with participants of other SPOTRIAS centers and NINDS.3. Monitor and record all telephone pages to the Greater Cincinnati/Northern Kentucky Stroke Teamthroughout the region (approximately 1000 per year)4. Document and collect clinical information from all patient evaluations by the Stroke Team at all hospitals(approximately 300+ per year) including reasons why patient was not treated with t-PA or as part of protocolas well as their all relevant data for the shared SPOTRIAS clinical database.5. Document all patients treated with standard intravenous t-PA or as part of acute treatment protocols(110-130 per year) as well as their all relevant data for the shared SPOTRIAS clinical database.6. Enroll approximately 150 fully evaluable subjects into the shared SPOTRIAS database per year.7. Coordinate all activities regarding IRBs at 12 hospitals as they related to SPOTRIAS projects (except forProjects 1 and 2 which will be handled by respective Project Coordinator for each Project).8. Insure the abstraction of all clinical data, informed consents of those subjects who agree to participate inthe shared patient and blood sample/tissue databases.9. Provide the administrative support for the Training Program detailed in separate section.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-G (21))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Cincinnati
United States
Zip Code
Lees, Kennedy R; Selim, Magdy H; Molina, Carlos A et al. (2016) Early Versus Late Assessment of Stroke Outcome. Stroke 47:1416-9
Kandadai, Madhuvanthi A; Mukherjee, Prithviraj; Shekhar, Himanshu et al. (2016) Microfluidic manufacture of rt-PA -loaded echogenic liposomes. Biomed Microdevices 18:48
Adeoye, Opeolu; Sucharew, Heidi; Khoury, Jane et al. (2015) Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke-Full Dose Regimen Stroke Trial. Stroke 46:2529-33
Chaisinanunkul, Napasri; Adeoye, Opeolu; Lewis, Roger J et al. (2015) Adopting a Patient-Centered Approach to Primary Outcome Analysis of Acute Stroke Trials Using a Utility-Weighted Modified Rankin Scale. Stroke 46:2238-43
Adeoye, Opeolu; Sucharew, Heidi; Khoury, Jane et al. (2015) Recombinant tissue-type plasminogen activator plus eptifibatide versus recombinant tissue-type plasminogen activator alone in acute ischemic stroke: propensity score-matched post hoc analysis. Stroke 46:461-4
Kandadai, Madhuvanthi A; Meunier, Jason M; Hart, Kimberley et al. (2015) Plasmin-loaded echogenic liposomes for ultrasound-mediated thrombolysis. Transl Stroke Res 6:78-87
Lu, A; Wagner, K R; Broderick, J P et al. (2014) Administration of S-methyl-L-thiocitrulline protects against brain injuries after intracerebral hemorrhage. Neuroscience 270:40-7
Adeoye, Opeolu; Knight, William A; Khoury, Jane et al. (2014) A matched comparison of eptifibatide plus rt-PA versus rt-PA alone in acute ischemic stroke. J Stroke Cerebrovasc Dis 23:e313-5
Stamova, Boryana; Jickling, Glen C; Ander, Bradley P et al. (2014) Gene expression in peripheral immune cells following cardioembolic stroke is sexually dimorphic. PLoS One 9:e102550
De Los Rios, Felipe; Kleindorfer, Dawn O; Guzik, Amy et al. (2014) Intravenous fibrinolysis eligibility: a survey of stroke clinicians' practice patterns and review of the literature. J Stroke Cerebrovasc Dis 23:2130-2138

Showing the most recent 10 out of 46 publications