Data for all SPOTRIAS projects has been managed for the previous five years, and will continue to be managed in the renewal period within a single integrated Columbia SPOTRIAS database designed and maintained under the oversight of BDM core leader Dr. Howard Andrews. Dr. Andrews is also director of the Data Coordinating Center (DCC) at the Columbia Mailman School of Public Health (MSPH), which is affiliated with the MSPH Biostatistics Department and which also serves the New York State Psychiatric Institute (NYSPl), a Columbia affiliate. The SPOTRIAS database resides on a physically and electronically secure server cluster maintained by the IT staff of NYSPl. Mr. Greg Neils, the Core B database manager, in consultation with Dr. Andrews and SPOTRIAS investigators and coordinators, and with the assistance of the Core B programmer, Mr. David Merie, designed and implemented the Columbia SPOTRIAS integrated SPOTRIAS database and the key functionalities that have been incorporated into the database over the past five years. Senior statisticians with primary appointments in the MSPH Biostatistics Department, Dr. Myunghee Paik and Dr. Ken Cheung, have traditionally overseen statistical consultation and data analysis for Clinical Trials in the Department of Neurology, have provided leadership for the SPOTRIAS statistical component for the past five years, and will continue to do so in the proposed renewal period. Dr. Eric Zarahn, Associate Research Scientist at the Neurological Institute, is an expert in neuroimaging data analysis, including Statistical Parametric Mapping and Dynamic Causal Modeling. Dr. Paik will provide overall leadership of the Statistics Component, statistical design consultation to DESERVE (Project 3, Discharge Educational Strategies in Stroke to Encourage Reduction of Vascular Events), and will oversee the work of the data analyst, Margaret Doyle, who conducts the analyses for Projects 1 and 2. Dr. Cheung is the senior statistician for NeuSTART (Project 1, Neuroprotection with Statin Therapy for Acute Recovery Trial), and Dr. Zarahn is senior statistician for Project 2, Recovery after Acute Stroke: a Multi-modal Investigation.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
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Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-R (46))
Project Start
Project End
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Columbia University (N.Y.)
New York
United States
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Yaghi, Shadi; Herber, Charlotte; Boehme, Amelia K et al. (2017) The Association between Diffusion MRI-Defined Infarct Volume and NIHSS Score in Patients with Minor Acute Stroke. J Neuroimaging 27:388-391
Dunn, Lauren E; Schweber, Adam B; Manson, Daniel K et al. (2016) Variability in Motor and Language Recovery during the Acute Stroke Period. Cerebrovasc Dis Extra 6:12-21
Boden-Albala, Bernadette; Stillman, Joshua; Roberts, Eric T et al. (2015) Comparison of Acute Stroke Preparedness Strategies to Decrease Emergency Department Arrival Time in a Multiethnic Cohort: The Stroke Warning Information and Faster Treatment Study. Stroke 46:1806-12
Boden-Albala, Bernadette; Southwick, Lauren; Carman, Heather (2015) Dietary interventions to lower the risk of stroke. Curr Neurol Neurosci Rep 15:15
Yaghi, Shadi; Herber, Charlotte; Willey, Joshua Z et al. (2015) Itemized NIHSS subsets predict positive MRI strokes in patients with mild deficits. J Neurol Sci 358:221-5
Lantigua, Hector; Ortega-Gutierrez, Santiago; Schmidt, J Michael et al. (2015) Subarachnoid hemorrhage: who dies, and why? Crit Care 19:309
Yaghi, Shadi; Elkind, Mitchell S V (2015) Lipids and Cerebrovascular Disease: Research and Practice. Stroke 46:3322-8
Dhamoon, Mandip S; McClure, Leslie A; White, Carole L et al. (2014) Quality of life after lacunar stroke: the Secondary Prevention of Small Subcortical Strokes study. J Stroke Cerebrovasc Dis 23:1131-7
Willey, Joshua Z; Khatri, Pooja; Khoury, Jane C et al. (2013) Variability in the use of intravenous thrombolysis for mild stroke: experience across the SPOTRIAS network. J Stroke Cerebrovasc Dis 22:318-22
Boden-Albala, Bernadette; Quarles, Leigh W (2013) Education strategies for stroke prevention. Stroke 44:S48-51

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