Core C: The Statistical Analysis and Bioinformatics Core of the University of Miami (UM) Udall Center builds on our experience in analysis of genes in PD over the previous twelve years. The goal of the Core is to support the needs of the Projects by applying powerful next-generation sequence analysis approaches, bioinformatics techniques, and established statistical analyses. The Core has integrated informatics, bioinformatics and statistical support. It takes advantage of existing resources within UM in the Hussman Institute for Human Genomics (HIHG) and Center for Computational Science (CCS). The core is lead by Dr. Beecham who is the director of informatics at the HIHG, an expert in genetic association analysis. He replaces Dr. Martin as PI, and has been a Project PI in our Udall Center since its inception. She remains on the core as a co-investigator. Members of the data management, computer, statistical, and bioinformatics staff of the HIHG staff will form the nucleus of the Statistical Analysis and Bioinformatics Core, addressing the projects'needs through the following specific aims: To provide the informatics to support database management, storage, and rapid retrieval of family history, clinical, risk factor, genotypic, DNA sequence and RNA expression data for the projects and clinical core. To provide analytical support for next-generation sequencing. We will provide support for the entire pipeline of next-generation sequencing data analysis;from data generation to statistical analysis and interpretation. The analyses include quality control, assembly, alignment, variant calling, functional annotation, and phenotype association analyses. To provide additional statistical analysis support for all projects and cores. We will conduct various analyses, including quality control, association analysis, parametric and non-parametric linkage, gene-gene and gene-environment interaction, biological pathway analysis, and copy-number variant detection and association.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS071674-05
Application #
8740572
Study Section
Special Emphasis Panel (ZNS1-SRB-E)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
5
Fiscal Year
2014
Total Cost
$193,219
Indirect Cost
$60,259
Name
University of Miami School of Medicine
Department
Type
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Hui, Ken Y; Fernandez-Hernandez, Heriberto; Hu, Jianzhong et al. (2018) Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Sci Transl Med 10:
Khorkova, Olga; Wahlestedt, Claes (2017) Oligonucleotide therapies for disorders of the nervous system. Nat Biotechnol 35:249-263
Wang, Xin; Li, Nuomin; Xiong, Nian et al. (2017) Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease. Mol Neurobiol 54:2878-2888
Jansen, Iris E; Ye, Hui; Heetveld, Sasja et al. (2017) Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biol 18:22
Barbier, E; Johnstone, A L; Khomtchouk, B B et al. (2017) Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2. Mol Psychiatry 22:1746-1758
Noyce, Alastair J; Kia, Demis A; Hemani, Gibran et al. (2017) Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. PLoS Med 14:e1002314
Wahlestedt, Claes (2017) Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets. Neuropsychopharmacology 42:374
Belle, Kinsley; Shabazz, Francelethia S; Nuytemans, Karen et al. (2017) Generation of disease-specific autopsy-confirmed iPSCs lines from postmortem isolated Peripheral Blood Mononuclear Cells. Neurosci Lett 637:201-206
Giri, Anamika; Mok, Kin Y; Jansen, Iris et al. (2017) Lack of evidence for a role of genetic variation in TMEM230 in the risk for Parkinson's disease in the Caucasian population. Neurobiol Aging 50:167.e11-167.e13
Heilig, M; Barbier, E; Johnstone, A L et al. (2017) Reprogramming of mPFC transcriptome and function in alcohol dependence. Genes Brain Behav 16:86-100

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