The Cognitive and Behavioral Core will provide psychometric assessments of neuropsychological functions for all projects. In addition, this Core will provide complementary support in the following two synergistic domains: (1) design, analysis, and development of novel cognitive neuropsychological tasks that will be used to assess the functionality ofthe fronto-striatal circuits impacted by Parkinson's disease (PD) and its treatment, and (2) neurocomputational and mathematical models of the fronto-striatal circuits for feedbackdriven reinforcement learning and neuro-economic decision making. These models will inform the development of new behavioral tasks and will provide behavioral measures to inform the analysis of the brain imaging data collected from these tasks.
The interdisciplinary integration of these cognitive and behavioral neuroscience methods into the proposed brain imaging and clinical aims is part of what will make this Center uniquely capable of furthering our understanding ofthe neural systems mediating higher cognitive functioning in PD patients.
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|Ng, Bernard; Varoquaux, Gael; Poline, Jean Baptiste et al. (2017) Distinct alterations in Parkinson's medication-state and disease-state connectivity. Neuroimage Clin 16:575-585|
|Vo, An; Sako, Wataru; Fujita, Koji et al. (2017) Parkinson's disease-related network topographies characterized with resting state functional MRI. Hum Brain Mapp 38:617-630|
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