Abstract

The Neuroimaging Resource Core (NRC; Core C) will provide support for Projects II and III of the University of Michigan Udall Center by performing the acquisition, processing, and parametric analysis and interpretation of all human subjects in vivo positron emission tomography (PET) and magnetic resonance imaging (MRI) data. The specific goals of the NRC are: 1) To perform [18F]FEOBV vesicular acetylcholine transporter and [11C]PE2I dopamine transporter PET on Parkinson disease (PD) subjects (N=60) and age- and gender-matched control (NC) subjects (N=15) at baseline and to repeat these assessments at two-year follow-up for the PD subjects. 2) To perform MRI, including T1- and T2-weighted, diffusion weighted (DWI), and resting state functional connectivity (rs-fMRI) sequences on PD subjects (N=60) and age- and gender-matched NC subjects (N=15) at baseline and to repeat these assessments at two-year follow-up for the PD subjects. 3) To perform parametric quantification of biochemical and physiological parameters from the PET data for subsequent statistical analysis in Projects II and III. 4) To perform parametric quantification of anatomical and functional parameters from the MRI data for subsequent statistical analysis in Projects II and III. 5) To perform advanced functional and anatomical network analyses using PET and MRI connectivity measures to provide metrics in support of the exploratory analyses of Projects II and III.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
2P50NS091856-06
Application #
9849378
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2019-09-18
Budget End
2020-08-31
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Miller, Nathaniel S; Chou, Kelvin L; Bohnen, Nicolaas I et al. (2018) Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease. Parkinsonism Relat Disord 48:54-60
Kalinin, Alexandr A; Allyn-Feuer, Ari; Ade, Alex et al. (2018) 3D Shape Modeling for Cell Nuclear Morphological Analysis and Classification. Sci Rep 8:13658
Beaulieu, Mélanie L; Müller, Martijn L T M; Bohnen, Nicolaas I (2018) Peripheral neuropathy is associated with more frequent falls in Parkinson's disease. Parkinsonism Relat Disord 54:46-50
Bohnen, Nicolaas I; Teipel, Stefan J (2018) Cholinergic forebrain density loss in Parkinson disease: More than just cognitive changes. Neurology 90:823-824
Rosso, Andrea L; Bohnen, Nicolaas I; Launer, Lenore J et al. (2018) Vascular and dopaminergic contributors to mild parkinsonian signs in older adults. Neurology 90:e223-e229
Bohnen, Nicolaas I; Grothe, Michel J; Ray, Nicola J et al. (2018) Recent advances in cholinergic imaging and cognitive decline-Revisiting the cholinergic hypothesis of dementia. Curr Geriatr Rep 7:1-11
Tang, Ming; Gao, Chao; Goutman, Stephen A et al. (2018) Model-Based and Model-Free Techniques for Amyotrophic Lateral Sclerosis Diagnostic Prediction and Patient Clustering. Neuroinformatics :
Nejad-Davarani, Siamak; Koeppe, Robert A; Albin, Roger L et al. (2018) Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [18F]-FEOBV. Mol Psychiatry :
Kotagal, Vikas; Albin, Roger L; Müller, Martijn L T M et al. (2018) Cardiovascular Risk Factor Burden in Veterans and Non-Veterans with Parkinson Disease. J Parkinsons Dis 8:153-160
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27

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