AIDS-RELATED RESEARCH DIVISION: AIDS RESEARCH CORE SUMMARY The AIDS-related Research Division (ARD) provides the scientific expertise and resources to enable efficient and productive use of nonhuman primates for AIDS-related research at the Washington National Primate Research Center (WaNPRC). As such, the Specific Aims of the Division are to 1) generate scientific resources by maintaining active research programs in key areas of AIDS-related research, 2) provide scientific leadership to the Service/Resource Cores within ARD, 3) provide focal points for collaborative research programs with investigators outside of WaNPRC, and 4) provide training and expertise to students, fellows and other research personnel. The ARD is comprised of three Core Staff scientists who maintain independently funded programs, which together constitute the AIDS Research Core. The AIDS Research Core conducts research in diverse and interrelated areas of primate lentiviruses and AIDS, including animal models for AIDS, virology, vaccine research, inflammation and immunology, pathogenesis, antiviral therapy and cure research, molecular biology, and microbiome. Additionally, two Service/Resource Cores, AIDS Virology and AIDS Immunology Cores, will operate under the direction of the Core Staff Scientists. The AIDS Virology Core, which has been in operation for the past 15 years, provides standardized procedures and assays to support AIDS-related research at WaNPRC, including tissue specimen processing, serology, viral load determination and production and characterization of viral stocks and antigens. In this granting period, we propose to also form a new core, the AIDS Immunology Core, to develop and refine cutting-edge procedures and assays that will better support the critical and growing need for services and expertise in AIDS immunology. The three Core Staff Scientists in ARD also serve as focal points to interact and collaborate with other research divisions and Service/Resource cores within WaNPRC as well as collaborators outside of WaNPRC who routinely utilize the scientific and technical expertise and resources at WaNPRC. All Core Staff Scientists of ARD participate in the training of personnel to conduct AIDS-related research, providing experience in a wide range of immunology, molecular biology, biochemistry and virology techniques. In addition to training students, fellows, research technologists and other professionals, members of ARD host visiting scholars, conduct seminars, organize research meetings to promote and utilize the intellectual and scientific resources at WaNPRC, and serve on academic and scientific organizations (e.g., various committees at UW, NIH study sections, advisory boards, editorial boards for scientific journals and organizing committees for national and international meetings) as well as the community at large.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Primate Research Center Grants (P51)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Veterinary Sciences
Primate Centers
United States
Zip Code
Manookin, Michael B; Patterson, Sara S; Linehan, Conor M (2018) Neural Mechanisms Mediating Motion Sensitivity in Parasol Ganglion Cells of the Primate Retina. Neuron 97:1327-1340.e4
Ramsingh, Arlene I; Gray, Steven J; Reilly, Andrew et al. (2018) Sustained AAV9-mediated expression of a non-self protein in the CNS of non-human primates after immunomodulation. PLoS One 13:e0198154
Grant, Kimberly S; Petroff, Rebekah; Isoherranen, Nina et al. (2018) Cannabis use during pregnancy: Pharmacokinetics and effects on child development. Pharmacol Ther 182:133-151
Dudley, Dawn M; Van Rompay, Koen K; Coffey, Lark L et al. (2018) Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. Nat Med 24:1104-1107
Herzfeld, David J; Kojima, Yoshiko; Soetedjo, Robijanto et al. (2018) Encoding of error and learning to correct that error by the Purkinje cells of the cerebellum. Nat Neurosci 21:736-743
Pallus, Adam C; Walton, Mark M G; Mustari, Michael J (2018) Response of supraoculomotor area neurons during combined saccade-vergence movements. J Neurophysiol 119:585-596
Weller, J Patrick; Horwitz, Gregory D (2018) Measurements of neuronal color tuning: Procedures, pitfalls, and alternatives. Vision Res 151:53-60
O'Connor, Megan A; Tisoncik-Go, Jennifer; Lewis, Thomas B et al. (2018) Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques. Nat Commun 9:3371
Ramsingh, Arlene I; Gray, Steven J; Reilly, Andrew et al. (2018) Correction: Sustained AAV9-mediated expression of a non-self protein in the CNS of non-human primates after immunomodulation. PLoS One 13:e0207077
Shum, Sara; Kirkwood, Jay S; Jing, Jing et al. (2018) Validated HPLC-MS/MS Method To Quantify Low Levels of Domoic Acid in Plasma and Urine after Subacute Exposure. ACS Omega 3:12079-12088

Showing the most recent 10 out of 261 publications