Abstract

-OVERALL TheOregonNationalPrimateResearchCenter(ONPRC),locatedontheWestCampusofOregonHealth& ScienceUniversity(OHSU),requestsfundstorenewgrantP51-OD011092forthenextfive-yearperiod(May 1,2019-April30,2024).Currentlyinits59thyearofoperation,theONPRChasservedabroadrangeoflocal, regional,andnationalinvestigatorsperformingbiomedicalresearchinnonhumanprimate(NHP)modelswith thegoalofimprovinghumanhealth.ThegoalsforthenextfundingperiodarereflectedinthefollowingSpecific Aims:1)Conductstate-of-the-artresearchthatadvancesunderstandingofcausesandthedevelopmentof preventions,treatments,andcuresfordebilitatinghumandiseases;?2)ProvideexceptionalNHPexpertiseand servicestoresearchersatthelocal,regional,andnationallevelstoadvanceNIH-andotherfederally- supportedresearchprograms;?3)Pursuethehigheststandardsofhumaneandresponsibleanimalcare;?and4) MentorandtrainthenextgenerationoftranslationalNHPresearchersandeducatethepublicaboutthe importanceofbiomedicalresearch.Toaccomplishtheseaims,supportisrequestedinsevenbroadareas. Theseareasare:(1)Administration,whichprovidestheadministrativeandservicesupportrequiredforall aspectsoftheONPRC(Governance,Director?sOffice,BusinessServices,Facilities,Improvementsand Modernization,InformationSystems,ResearchLibrary,andResearchSafety);?(2)AnimalServices[Resources &Logistics,Operations,PathologyServices,SurgicalServices,BehavioralServices,EducationandTraining, ClinicalMedicine,andNHPResources(Obese,Aging,InfectiousDisease,andJapaneseMacaque)];?(3)Core ScienceServices[ResearchCores(AssistedReproductiveTechnologies,Bioinformatics&Biostatistics, EndocrineTechnologies,FlowCytometry,IntegratedPathology,MolecularTechnologies,MolecularVirology, MagneticResonanceImaging(MRI),andPrimateGenetics)];?(4)ScientificComponents,includingsupportfor ScientificDivisions(CardiometabolicHealth,Genetics,Neuroscience,Pathobiology&Immunology,and Reproductive&DevelopmentalSciences);?(5)PilotResearchProgram;?(6)OutreachandCommunity Engagement;?and(7)NPRCConsortium-BasedActivities. ONPRC?soverarchinggoalistodevelop,study,andshareNHPmodelsthatcaninformthecausesofhuman diseases,leadingtobetterpreventions,treatments,andcures.TheONPRCachievesthisgoalbysupporting translationalresearchandexpertiseinmodelsthatareprovidedlocally,regionally,andnationallyona collaborativebasis.Thehostinstitution,OHSU,recognizestheONPRCasoneoftheuniversity?s?topfive? strengthsandhaspledgedtocontinuesupportforprogrammaticintegrationandinfrastructuredevelopment.

Public Health Relevance

-OVERALL TheOregonNationalPrimateResearchCenter(ONPRC)isanestablishednationalresourcethathasasits primarymissiontheimprovementofhumanhealthandqualityoflifethroughsupportofexceptionalnonhuman primate(NHP)researchprogramsthatadvanceourknowledgeofthecauses,preventions,treatments,and curesofdebilitatingdiseases.TheONPRChostsrobustandwell-developedinternalresearchprograms,which arecomplementedbycollaborativeresearchprogramsthatservethegreaterbiomedicalresearchcommunity. TheONPRCmaintainsthefacilities,expertise,andinfrastructurerequiredtoconductthemostadvanced biomedicalresearchusingNHPsasmodelsofhumanhealthanddisease.Moreover,theONPRCcanmeet theneedsofnewemergingareasofbasicresearchinwhichtheNHPmodeliscritical,aswellastranslational researchinitiativesthatarehighlyinterdisciplinary.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
5P51OD011092-61
Application #
9973200
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Hild, Sheri Ann
Project Start
1997-05-01
Project End
2024-04-30
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
61
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
Primate Centers
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Kolb, Philipp; Sijmons, Steven; McArdle, Matthew R et al. (2018) Identification and functional characterization of a novel Fc gamma-binding glycoprotein in Rhesus Cytomegalovirus. J Virol :
Hansen, Scott G; Zak, Daniel E; Xu, Guangwu et al. (2018) Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine. Nat Med 24:130-143
Slifka, Mark K; Amanna, Ian J (2018) Dengue Serostatus and Dengue Vaccine Safety and Efficacy. N Engl J Med 379:1968
McGill, Trevor J; Wilson, David J; Stoddard, Jonathan et al. (2018) Cell Transplantation for Retinal Degeneration: Transition from Rodent to Nonhuman Primate Models. Adv Exp Med Biol 1074:641-647
Xu, Jing; Xu, Fuhua; Lawson, Maralee S et al. (2018) Anti-Müllerian hormone is a survival factor and promotes the growth of rhesus macaque preantral follicles during matrix-free culture. Biol Reprod 98:197-207
Tao, Yong; Tartia, Alina; Lawson, Maralee et al. (2018) Can peri-ovulatory putrescine supplementation improve egg quality in older infertile women? J Assist Reprod Genet :
Ortiz, Alexandra M; Flynn, Jacob K; DiNapoli, Sarah R et al. (2018) Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques. Nat Med 24:1313-1316
Hirsch, Alec J; Roberts, Victoria H J; Grigsby, Peta L et al. (2018) Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology. Nat Commun 9:263
Okoye, Afam A; Hansen, Scott G; Vaidya, Mukta et al. (2018) Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound. Nat Med 24:1430-1440
Simpson, Elizabeth M; Korecki, Andrea J; Fornes, Oriol et al. (2018) New MiniPromoter Ple345 (NEFL) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina. Hum Gene Ther :

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