The Wisconsin National Primate Research Center (WNPRC) base operating grant supports services and resources for research addressing human health issues utilizing non-human primate (NHP) models. Located on the campus of the University of Wisconsin-Madison, the WNPRC is fully integrated into the mission of UW-Madison, including research and training links in the several schools and colleges, basic science and clinical departments, and interdisciplinary centers and institutes. In addition, WNPRC investigators have strong research collaborations with scientists across the U.S. and internationally. The WNPRC provides a rich and integrated portfolio of cutting-edge services, resources, and scientific expertise that support NHP research with high impact and direct relevance to human and animal health and disease. This P51 Revision application requests support for maintenance and development of common marmosets (Callithrix jacchus) recently acquired from the New England Primate Research Center (NEPRC).
Our specific aims to support these animals are as follows:
Aim 1. To provide excellent animal holding facilities and primary enclosures for the marmosets transferred from the NEPRC.
Aim 2. To implement exceptional, USDA/PHS/OLAW/AAALAC compliant husbandry and veterinary medical practices for the marmosets transferred from the NEPRC.
Aim 3. To implement appropriate genetic and reproductive management for the transferred marmosets.
Aim 4. To implement a prudent financial plan to support the transferred marmosets as ORIP support for the animals is progressively reduced In accomplishing the foregoing Specific Aims, we will then be poised to advance our Center goals to enhance the WNPRC marmoset colony as a national resource-commensurate with demand of investigators-and, develop WNPRC resource initiatives, such as a transgenic marmoset facility.

Public Health Relevance

The Wisconsin National Primate Research Center (WNPRC) provides a rich and integrated portfolio of cutting-edge services, resources, and scientific expertise that support non-human primate (NHP) research with high impact and direct relevance to human and animal health and disease. With continued support for maintenance and development of common marmosets (Callithrix jacchus) recently acquired from the New England Primate Research Center (NEPRC), we will be poised to advance our Center goals to enhance the WNPRC marmoset colony as a national resource-commensurate with demand of investigators-and, develop WNPRC resource initiatives, such as a transgenic marmoset facility.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
3P51OD011106-54S1
Application #
9003677
Study Section
Special Emphasis Panel (ZRG1-BBBP-T (46))
Program Officer
Harding, John D
Project Start
1997-06-10
Project End
2017-04-30
Budget Start
2015-09-07
Budget End
2016-04-30
Support Year
54
Fiscal Year
2015
Total Cost
$407,357
Indirect Cost
$97,863
Name
University of Wisconsin Madison
Department
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Sutton, Matthew S; Ellis-Connell, Amy; Moriarty, Ryan V et al. (2018) Acute-Phase CD4+ T Cell Responses Targeting Invariant Viral Regions Are Associated with Control of Live Attenuated Simian Immunodeficiency Virus. J Virol 92:
Aktas, Zeynep; Rao, Hongyu; Slauson, Sarah R et al. (2018) Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork. Invest Ophthalmol Vis Sci 59:298-310
Sauter, Monica M; Kolb, Aaron W; Brandt, Curtis R (2018) Toll-like receptors 4, 5, 6 and 7 are constitutively expressed in non-human primate retinal neurons. J Neuroimmunol 322:26-35
Kohn, Luci Ann P; Lubach, Gabriele R (2018) Postcranial Skeletal Differences in Free-Range and Captive-Born Primates. Anat Rec (Hoboken) :
Kraynak, Marissa; Colman, Ricki J; Flowers, Matthew T et al. (2018) Ovarian estradiol supports sexual behavior but not energy homeostasis in female marmoset monkeys. Int J Obes (Lond) :
Jones, Corinne A; Duffy, Mary K; Hoffman, Sarah A et al. (2018) Vocalization development in common marmosets for neurodegenerative translational modeling. Neurol Res 40:303-311
Rhoads, Timothy W; Burhans, Maggie S; Chen, Vincent B et al. (2018) Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys. Cell Metab 27:677-688.e5
Suknuntha, Kran; Tao, Lihong; Brok-Volchanskaya, Vera et al. (2018) Optimization of Synthetic mRNA for Highly Efficient Translation and its Application in the Generation of Endothelial and Hematopoietic Cells from Human and Primate Pluripotent Stem Cells. Stem Cell Rev 14:525-534
Zhao, Gengyan; Liu, Fang; Oler, Jonathan A et al. (2018) Bayesian convolutional neural network based MRI brain extraction on nonhuman primates. Neuroimage 175:32-44
Chang, T Arthur; Bondarenko, Gennadiy I; Gerami-Naini, Behzad et al. (2018) Trophoblast differentiation, invasion and hormone secretion in a three-dimensional in vitro implantation model with rhesus monkey embryos. Reprod Biol Endocrinol 16:24

Showing the most recent 10 out of 334 publications