Abstract

The Wisconsin National Primate Research Center (WNPRC) is one of seven federally supported National Primate Research Centers and the only one in the Midwest. WNPRC's mission is to increase the understanding of basic primate biology and to improve human health and quality of life through research. To accomplish this, the WNPRC helps discover treatments, preventions and cures for human disease; generates new knowledge of primate biology, from the molecular and whole animal levels to the understanding of primate ecosystems; facilitates research progress by providing expertise, resources and training to scientists worldwide; and collects primate information and disseminates to the research community and to the public.

Public Health Relevance

The Wisconsin National Primate Research Center (WNPRC) base operating grant supports services and resources for research addressing human health issues utilizing non-human primate (NHP) models. The WNPRC provides a rich and integrated portfolio of cutting-edge services, resources, and scientific expertise that support NHP research with high impact and direct relevance to human and animal health and disease. With ongoing additions to WNPRC infrastructure, and expansion of the Center's scientific components and collaborations, the WNPRC is poised to advance the translation of NHP research findings into new remedies for some of our society's most pressing medical problems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
2P51OD011106-56
Application #
9280445
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Hild, Sheri Ann
Project Start
1997-06-10
Project End
2022-04-30
Budget Start
2017-07-21
Budget End
2018-04-30
Support Year
56
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
Graduate Schools
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Rhoads, Timothy W; Burhans, Maggie S; Chen, Vincent B et al. (2018) Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys. Cell Metab 27:677-688.e5
Suknuntha, Kran; Tao, Lihong; Brok-Volchanskaya, Vera et al. (2018) Optimization of Synthetic mRNA for Highly Efficient Translation and its Application in the Generation of Endothelial and Hematopoietic Cells from Human and Primate Pluripotent Stem Cells. Stem Cell Rev 14:525-534
Zhao, Gengyan; Liu, Fang; Oler, Jonathan A et al. (2018) Bayesian convolutional neural network based MRI brain extraction on nonhuman primates. Neuroimage 175:32-44
Chang, T Arthur; Bondarenko, Gennadiy I; Gerami-Naini, Behzad et al. (2018) Trophoblast differentiation, invasion and hormone secretion in a three-dimensional in vitro implantation model with rhesus monkey embryos. Reprod Biol Endocrinol 16:24
Metzger, Jeanette M; Moore, Colleen F; Boettcher, Carissa A et al. (2018) In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration. NPJ Parkinsons Dis 4:22
Vermilyea, Scott C; Emborg, Marina E (2018) The role of nonhuman primate models in the development of cell-based therapies for Parkinson's disease. J Neural Transm (Vienna) 125:365-384
Colman, Ricki J (2018) Non-human primates as a model for aging. Biochim Biophys Acta Mol Basis Dis 1864:2733-2741
Schmitt, Kimberly; Curlin, James; Kumar, Dipu Mohan et al. (2018) SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2. J Med Primatol 47:298-301
Slukvin, Igor I; Uenishi, Gene I (2018) Arterial identity of hemogenic endothelium: a key to unlock definitive hematopoietic commitment in hPSC cultures. Exp Hematol :
Macdonald, Jacob A; Corrado, Philip A; Nguyen, Sydney M et al. (2018) Uteroplacental and Fetal 4D Flow MRI in the Pregnant Rhesus Macaque. J Magn Reson Imaging :

Showing the most recent 10 out of 334 publications