Abstract

The California National Primate Research Center (CNPRC) Is one of eight National Primate Research Centers (NPRCs) funded by the National Institutes of Health, National Center for Research Resource. This renewal application seeksisupport for Administrative Services, Primate Services, Core Science Services, Research Units and Modernization and Improvement. To enhance the CNPRC's ability to serve as a regional, national, and international resource and provide the infrastructure support essential to conduct successful research on nonhuman primates, we are proposing the following specific aims. 1) Advance translational research through the development of nonhuman primate models; 2) Foster an environment that encourages and emphasizes the scientific expertise that is critical to carry out the mission of the NPRC Program and the CNPRC; 3) Encourage partnerships to maximize the research investment; 4) Enhance the research infrastructure; 5) Strengthen the research workforce; 6) Increase efficiencies in the use of CNPRC resources.

Public Health Relevance

The CNPRC will expand collaborations to enhance translational research through the development of new nonhuman primate models of disease by utilizing basic knowledge and technologies of Staff Scientists and scientists outside of the CNPRC.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
3P51OD011107-53S1
Application #
8851027
Study Section
Special Emphasis Panel (ZRR1)
Program Officer
Harding, John D
Project Start
1997-05-01
Project End
2015-04-30
Budget Start
2014-07-01
Budget End
2015-04-30
Support Year
53
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Midic, Uros; Goheen, Benjamin; Vincent, Kailey A et al. (2018) Changes in gene expression following long-term in vitro exposure of Macaca mulatta trophoblast stem cells to biologically relevant levels of endocrine disruptors. Reprod Toxicol 77:154-165
Méndez-Lagares, Gema; Lu, Ding; Chen, Connie et al. (2018) Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success. J Immunol 200:1124-1132
Vandeleest, J J; Capitanio, J P; Hamel, A et al. (2018) Social stability influences the association between adrenal responsiveness and hair cortisol concentrations in rhesus macaques. Psychoneuroendocrinology 100:164-171
Laing, Steven T; Merriam, David; Shock, Barbara C et al. (2018) Idiopathic Colitis in Rhesus Macaques Is Associated With Dysbiosis, Abundant Enterochromaffin Cells and Altered T-Cell Cytokine Expression. Vet Pathol 55:741-752
Flahou, Bram; Rossi, Mirko; Bakker, Jaco et al. (2018) Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs. ISME J 12:77-86
Walker, Cheryl K; VandeVoort, Catherine A; Li, Chin-Shang et al. (2018) Adiposity and weight gain during pregnancy associate independently with behavior of infant rhesus monkeys (Macaca mulatta). Dev Psychobiol 60:629-638
McCowan, Brenda; Beisner, Brianne; Hannibal, Darcy (2018) Social management of laboratory rhesus macaques housed in large groups using a network approach: A review. Behav Processes 156:77-82
Almodovar, Sharilyn; Swanson, Jessica; Giavedoni, Luis D et al. (2018) Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines in SHIVnef-Infected Macaques. Viral Immunol 31:206-222
Reis, Edimara S; Berger, Nadja; Wang, Xin et al. (2018) Safety profile after prolonged C3 inhibition. Clin Immunol 197:96-106
Amedee, Angela M; Phillips, Bonnie; Jensen, Kara et al. (2018) Early Sites of Virus Replication After Oral SIVmac251 Infection of Infant Macaques: Implications for Pathogenesis. AIDS Res Hum Retroviruses 34:286-299

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