This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The Division of Reproductive Sciences conducts basic and applied research on aspects of reproductive biology relevant to understanding human reproduction and to controlling reproductive disorders and fertility. In addition, the division, as part of the Oregon Health & Science University, provides training for individuals entering science-oriented careers (e.g., pre- and postdoctoral fellows, new faculty in the Women's Reproductive Health Research [WRHR] scholar program, OB/GYN) and research experience for others (e.g., school teachers). Finally, the division serves as a regional, national and international resource for reproductive research, especially as it relates to nonhuman primates. The research of Division scientists (Dr. R.L. Stouffer, Head) focuses on understanding the central (neural) and peripheral (endocrine, paracrine, and autocrine) mechanisms controlling reproductive function, primarily in females. Research projects span the continuum of reproduction that begins with gamete (egg and sperm) development and ends with the birth and nursing of an offspring. A general theme apparent in all laboratories is the utilization of Old World monkeys as a model for whole animal, cellular and molecular studies of direct relevance to human reproduction. Through a better understanding of basic reproductive processes, investigators are considering the etiology and potential treatment of reproductive disorders, as well as novel approaches for contraception. Also, researchers are considering unique nonhuman models for future biomedical research through assisted reproductive technologies, including the study and application of primate embryonic stem cells. Many advances can be directly translated to issues in women's health, cancer, diabetes, cardiovascular research, aging, obesity, neuroscience and behavior.
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