This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The ovulatory gonadotropin surge initiates events in the primate follicle that are required for oocyte release and the subsequent formation of the corpus luteum. One event critical for follicle rupture includes the conversion of arachidonic acid (AA) into prostaglandins (PGs) via the actions of the enzyme prostaglandin-endoperoxide synthase 2 (PTGS2). From research utilizing rodents, domesticated animal species and primates, a significant role for AA-derived prostaglandins (i.e., PGE2 and PGF2alpha) in the regulation of luteal function has also been suggested. In the primate corpus luteum, however, the role(s) of prostaglandins remain poorly defined. Therefore, a genomic approach was utilized to determine if genes encoding proteins involved in prostaglandin synthesis, metabolism, and signaling are differentially or coordinately regulated in the corpus luteum through the menstrual cycle in rhesus macaques.
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