This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The endothelium regulates vascular thrombosis, intimal hyperplasia, inflammation, and angiogenesis. To enhance the endothelialization of vascular constructs we have characterized circulating endothelial progenitor cells (CECs) from human, baboon, and rhesus peripheral blood. We have developed baboon models for assessing early blood reactions (thrombosis), and vascular graft healing (intimal hyperplasia) following surgical placement of conventional ePTFE grafts. In the next phase of this work, CECs will be cultured onto ePTFE grafts, further characterized with respect to expression of key mediators, and subsequently evaluated in the baboon thrombosis and arterial implant models. Concurrently, blood interactions of CEC-elastin-collagen constructs from Bob Nerem's group are evaluated both in vitro and in vivo, in the baboon model of arterial thrombosis.
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