This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Endometriosis is a chronic disease where endometrium-like tissue forms lesions at sites outside the uterus. Our goal is to test potential new therapies for endometriosis. To do this we have developed a novel model in which we transplant rhesus macaque endometrium subcutaneously into immunodeficient transgenic RAG-2/c-gamma KO mice, which are incapable of rejecting xenografts. The endometrial xenografts grow in response to estrogen and undergo cyclic breakdown similar to endometriosis in women. Our plan is to treat the mice with novel therapies including progesterone receptor (PR)A/PRB-specific ligands, estrogen receptor (ER) beta antagonists etc.
Our aim i s to assess the safety and efficacy of these therapies prior to developing clinical trials in women.
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