Abstract

Because aged nonhuman primates show ?-amyloid (A?) deposition in senile plaques and blood vessels similar to that seen in human aging and AD, C-terminal-specific antibodies to A?40 and A?42 were used to investigate A? peptide length in the brains of 11 aged rhesus monkeys and a 59-year-old chimpanzee. In contrast to AD, where the earliest and most prominent form of A? in senile plaques is A?42 in the monkey, A?40-positive plaques predominated. The ratio of A?40:A?42-positive plaques averaged 2.08 in the monkey, as compared to a mean ratio of 0.37 in 68 human AD subjects (p < 0.001). A?40 was also more prominent in the chimpanzee than in humans. Possible explanations for these findings include species differences in the cleavage of A? from the amyloid precursor protein or in the activity of a putative carboxy peptidase forming A?40 from A?42 in situ.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
3P51RR000165-37S1
Application #
2711873
Study Section
Project Start
Project End
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Lacreuse, Agnès; Parr, Lisa; Chennareddi, Lakshmi et al. (2018) Age-related decline in cognitive flexibility in female chimpanzees. Neurobiol Aging 72:83-88
Meng, Yuguang; Hu, Xiaoping; Zhang, Xiaodong et al. (2018) Diffusion tensor imaging reveals microstructural alterations in corpus callosum and associated transcallosal fiber tracts in adult macaques with neonatal hippocampal lesions. Hippocampus 28:838-845
Mylvaganam, Geetha H; Chea, Lynette S; Tharp, Gregory K et al. (2018) Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV. JCI Insight 3:
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Ploquin, Mickaël J; Casrouge, Armanda; Madec, Yoann et al. (2018) Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage. J Int AIDS Soc 21:e25144
Fonseca, Jairo A; McCaffery, Jessica N; Caceres, Juan et al. (2018) Inclusion of the murine IgG? signal peptide increases the cellular immunogenicity of a simian adenoviral vectored Plasmodium vivax multistage vaccine. Vaccine 36:2799-2808
Tedesco, Dana; Thapa, Manoj; Chin, Chui Yoke et al. (2018) Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic ?? T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease. Gastroenterology 154:2178-2193
Robinson, Amy A; Abraham, Carmela R; Rosene, Douglas L (2018) Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys. Geroscience 40:31-47
Walker, Lary C (2018) Sabotage by the brain's supporting cells helps fuel neurodegeneration. Nature 557:499-500
Mascaro, Jennifer S; Rentscher, Kelly E; Hackett, Patrick D et al. (2018) Preliminary evidence that androgen signaling is correlated with men's everyday language. Am J Hum Biol 30:e23136

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