Abstract

Work has continued in the past year to improve artificial breeding methods for the chimpanzee. Methods for superovulation have been developed using human menopausal gonadotropins. The success rate of A.I. has been raised to over 80% for a single insemination when specific parameters of the inseminated cycle have been met. At this time such identification is by observation of the spontaneous cycle, however, future work will be directed to iatrogenic initiation of such highly fertile cycles. The alteration in fertility is likely associated with endometrial development and alteration of implantation rate. As a consequence of a restriction in breeding of the common chimpanzee, we are increasing efforts directed to creation and cryobanking of embryos created using In vitro fertilization and ICSI. To date embryos have been banked from the common chimpanzee (P. Troglodytes) and the sooty mangabey (c. Atys). In addition, we are studying the potential effects of fish an tifreeze proteins as cryoprotectants for semen storage.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000165-38
Application #
6277481
Study Section
Project Start
1998-05-01
Project End
1999-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
38
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Wakeford, Alison G P; Morin, Elyse L; Bramlett, Sara N et al. (2018) A review of nonhuman primate models of early life stress and adolescent drug abuse. Neurobiol Stress 9:188-198
Singh, Arun; Jenkins, Meagan A; Burke Jr, Kenneth J et al. (2018) Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates. Cell Rep 22:941-952
Maddox, S A; Kilaru, V; Shin, J et al. (2018) Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD. Mol Psychiatry 23:658-665
Li, Chun-Xia; Kempf, Doty J; Tong, Frank C et al. (2018) Longitudinal MRI Evaluation of Ischemic Stroke in the Basal Ganglia of a Rhesus Macaque (Macaca mulatta) with Seizures. Comp Med :
Lacreuse, Agnès; Parr, Lisa; Chennareddi, Lakshmi et al. (2018) Age-related decline in cognitive flexibility in female chimpanzees. Neurobiol Aging 72:83-88
Meng, Yuguang; Hu, Xiaoping; Zhang, Xiaodong et al. (2018) Diffusion tensor imaging reveals microstructural alterations in corpus callosum and associated transcallosal fiber tracts in adult macaques with neonatal hippocampal lesions. Hippocampus 28:838-845
Mylvaganam, Geetha H; Chea, Lynette S; Tharp, Gregory K et al. (2018) Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV. JCI Insight 3:
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Ploquin, Mickaël J; Casrouge, Armanda; Madec, Yoann et al. (2018) Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage. J Int AIDS Soc 21:e25144
Fonseca, Jairo A; McCaffery, Jessica N; Caceres, Juan et al. (2018) Inclusion of the murine IgG? signal peptide increases the cellular immunogenicity of a simian adenoviral vectored Plasmodium vivax multistage vaccine. Vaccine 36:2799-2808

Showing the most recent 10 out of 912 publications